Role of cholesterol in fusion of Semliki Forest virus with membranes

M. C. Kielian, A. Helenius

Research output: Contribution to journalArticle

140 Scopus citations

Abstract

The low pH-triggered membrane fusion activity of Semliki Forest virus is dependent on the presence of cholesterol in the target membrane. When liposomes containing phospholipids and cholesterol analogs were used, fusion activity was observed with steroids which did not have a planar nucleus or an isooctyl side chain at C-17, but fusion activity was not observed when analogs which lacked the 3β-OH group were used. Binding of virus to liposomes at low pH was similarly, but not totally, dependent on the presence of a 3β-OH sterol.

Original languageEnglish (US)
Pages (from-to)281-283
Number of pages3
JournalJournal of virology
Volume52
Issue number1
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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