Role of Cell-mediated Immunity in Tumor Eradication by Hyperthermia

Alan A. Alfieri, Eric W. Hahn, Jae Ho Kim

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19 Scopus citations

Abstract

A single hyperthermic treatment (44.5° for 20 min) which results in successful local control of a 7-day intradermally growing fibrosarcoma in intact mice fails to permanently control tumor growth in immunodeficient nu/nu (BALB/c) or immunosuppressed (whole-body radiation, 500 rads) mice. Studies were designed to determine whether humoral or cellular-mediated factors were responsible. Nude mice were reconstituted with either heterozygotic (nu/+) sensitized or nonsensitized splenic T-cells. Similarly, semi-syngeneic immunosuppressed BALB/c × C57BL/6 F1 hybrids were reconstituted with homologous sensitized and nonsensitized T-cells or sera prior to hyperthermic treatment of a 7-day intradermal Meth-A implant. Successful local tumor control by hyperthermia was effected in those animals reconstituted with ≥1.8 × 107 splenic T-cells but not in those with sera. The inhibition of macrophage activity (chronic silica, i.p.) could substitute for whole-body radiation immunosuppression. These studies indicate that a thermally induced tumor cure would appear to be mediated by an activated macrophage-antigen-T-cell interaction which may be dependent on the initial expression of cell-mediated antitumor immunity that may be generated only in response to immunogenic tumors.

Original languageEnglish (US)
Pages (from-to)1301-1305
Number of pages5
JournalCancer Research
Volume41
Issue number4
Publication statusPublished - Apr 1 1981

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Alfieri, A. A., Hahn, E. W., & Kim, J. H. (1981). Role of Cell-mediated Immunity in Tumor Eradication by Hyperthermia. Cancer Research, 41(4), 1301-1305.