Role of cell-mediated immunity in tumor eradication by hyperthermia

A. A. Alfieri, E. W. Hahn, J. H. Kim

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A single hyperthermic treatment (44.5° for 20 min) which results in successful local control of a 7-day intradermally growing fibrosarcoma in intact mice fails to permanently control tumor growth in immunodeficient nu/nu (BALB/c) or immunosuppressed (whole-body radiation, 500 rads) mice. Studies were designed to determine whether humora or cellular-mediated factors were responsible. Nude mice were reconstituted with either heterozygotic (nu/+)sensitized or nonsensitized splenic T-cell. Similarly, semisyngeneic immunosuppressed BALB/c x C57BL/6F, hybrids were reconstituted with homologous sensitized and nonsensilized T-cells or sera prior to hyperthermic treatment of a 7-day intradermal Meth-A implant. successful local tumor control by hyperthermia was effected in those animals reconstituted with ≥1.8 x 107 splenic T-cells but not in those with sera. The inhibition of macrophage activity (chronic silica, i.p.) could substitute for whole-body radiation immunosuppression. These studies indicate that a thermally induced tumor cure would appear to be mediated by an activated macrophage-antigen-T-cell interaction which may be dependent on the initial expression of cell-mediated antitumor immunity that may be generated only in response to immunogenic tumors.

Original languageEnglish (US)
Pages (from-to)1301-1305
Number of pages5
JournalCancer Research
Volume41
Issue number4
StatePublished - 1981
Externally publishedYes

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Cellular Immunity
Fever
T-Lymphocytes
Whole-Body Irradiation
Neoplasms
Macrophages
Fibrosarcoma
Serum
Nude Mice
Cell Communication
Silicon Dioxide
Immunosuppression
Antigens
Therapeutics
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Alfieri, A. A., Hahn, E. W., & Kim, J. H. (1981). Role of cell-mediated immunity in tumor eradication by hyperthermia. Cancer Research, 41(4), 1301-1305.

Role of cell-mediated immunity in tumor eradication by hyperthermia. / Alfieri, A. A.; Hahn, E. W.; Kim, J. H.

In: Cancer Research, Vol. 41, No. 4, 1981, p. 1301-1305.

Research output: Contribution to journalArticle

Alfieri, AA, Hahn, EW & Kim, JH 1981, 'Role of cell-mediated immunity in tumor eradication by hyperthermia', Cancer Research, vol. 41, no. 4, pp. 1301-1305.
Alfieri, A. A. ; Hahn, E. W. ; Kim, J. H. / Role of cell-mediated immunity in tumor eradication by hyperthermia. In: Cancer Research. 1981 ; Vol. 41, No. 4. pp. 1301-1305.
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