Role of brain-derived neurotrophic factor in depression-related behaviour - could it explain the higher incidence in females?

Anita E. Autry-Dixon, Lisa M. Monteggia

Research output: Contribution to journalArticle

Abstract

Major depressive disorder (MDD) is known to have a significant genetic component and is twice as prevalent in women as in men. However, little is known concerning the biological underpinnings of the relationship of gender to MDD. Recent data suggest that brain-derived neurotrophic factor (BDNF) is essential for normal depression behaviour and antidepressant efficacy and, furthermore, may contribute to gender differences in depression-related behaviour. Here, we will review data regarding the role of BDNF in mediating depression-related behaviour and antidepressant efficacy, with emphasis on how it may impact gender differences observed in MDD.

Original languageEnglish (US)
Pages (from-to)102-104
Number of pages3
JournalEuropean Psychiatric Review
Volume4
Issue number2
StatePublished - Dec 1 2011
Externally publishedYes

Fingerprint

Brain-Derived Neurotrophic Factor
Major Depressive Disorder
Depression
Antidepressive Agents
Incidence

Keywords

  • Animal model
  • Behaviour
  • Brain-derived neurotrophic factor
  • Depression
  • Gender
  • Major depressive disorder
  • Stress

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Role of brain-derived neurotrophic factor in depression-related behaviour - could it explain the higher incidence in females? / Autry-Dixon, Anita E.; Monteggia, Lisa M.

In: European Psychiatric Review, Vol. 4, No. 2, 01.12.2011, p. 102-104.

Research output: Contribution to journalArticle

@article{bc25016d8aeb471b824b0a20344bd825,
title = "Role of brain-derived neurotrophic factor in depression-related behaviour - could it explain the higher incidence in females?",
abstract = "Major depressive disorder (MDD) is known to have a significant genetic component and is twice as prevalent in women as in men. However, little is known concerning the biological underpinnings of the relationship of gender to MDD. Recent data suggest that brain-derived neurotrophic factor (BDNF) is essential for normal depression behaviour and antidepressant efficacy and, furthermore, may contribute to gender differences in depression-related behaviour. Here, we will review data regarding the role of BDNF in mediating depression-related behaviour and antidepressant efficacy, with emphasis on how it may impact gender differences observed in MDD.",
keywords = "Animal model, Behaviour, Brain-derived neurotrophic factor, Depression, Gender, Major depressive disorder, Stress",
author = "Autry-Dixon, {Anita E.} and Monteggia, {Lisa M.}",
year = "2011",
month = "12",
day = "1",
language = "English (US)",
volume = "4",
pages = "102--104",
journal = "European Psychiatric Review",
issn = "1758-1354",
publisher = "Touch Briefings",
number = "2",

}

TY - JOUR

T1 - Role of brain-derived neurotrophic factor in depression-related behaviour - could it explain the higher incidence in females?

AU - Autry-Dixon, Anita E.

AU - Monteggia, Lisa M.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Major depressive disorder (MDD) is known to have a significant genetic component and is twice as prevalent in women as in men. However, little is known concerning the biological underpinnings of the relationship of gender to MDD. Recent data suggest that brain-derived neurotrophic factor (BDNF) is essential for normal depression behaviour and antidepressant efficacy and, furthermore, may contribute to gender differences in depression-related behaviour. Here, we will review data regarding the role of BDNF in mediating depression-related behaviour and antidepressant efficacy, with emphasis on how it may impact gender differences observed in MDD.

AB - Major depressive disorder (MDD) is known to have a significant genetic component and is twice as prevalent in women as in men. However, little is known concerning the biological underpinnings of the relationship of gender to MDD. Recent data suggest that brain-derived neurotrophic factor (BDNF) is essential for normal depression behaviour and antidepressant efficacy and, furthermore, may contribute to gender differences in depression-related behaviour. Here, we will review data regarding the role of BDNF in mediating depression-related behaviour and antidepressant efficacy, with emphasis on how it may impact gender differences observed in MDD.

KW - Animal model

KW - Behaviour

KW - Brain-derived neurotrophic factor

KW - Depression

KW - Gender

KW - Major depressive disorder

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=84857580754&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857580754&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 102

EP - 104

JO - European Psychiatric Review

JF - European Psychiatric Review

SN - 1758-1354

IS - 2

ER -