Role for calcium signaling in manganese neurotoxicity

Omamuyovwi M. Ijomone, Oritoke M. Aluko, Comfort O.A. Okoh, Airton Cunha Martins, Michael Aschner

Research output: Contribution to journalReview article

Abstract

Background: Calcium is an essential macronutrient that is involved in many cellular processes. Homeostatic control of intracellular levels of calcium ions [Ca2+] is vital to maintaining cellular structure and function. Several signaling molecules are involved in regulating Ca2+ levels in cells and perturbation of calcium signaling processes is implicated in several neurodegenerative and neurologic conditions. Manganese [Mn] is a metal which is essential for basic physiological functions. However, overexposure to Mn from environmental contamination and workplace hazards is a global concern. Mn overexposure leads to its accumulation in several human organs particularly the brain. Mn accumulation in the brain results in a manganism, a Parkinsonian-like syndrome. Additionally, Mn is a risk factor for several neurodegenerative diseases including Parkinson's disease and Alzheimer's disease. Mn neurotoxicity also affects several neurotransmitter systems including dopaminergic, cholinergic and GABAergic. The mechanisms of Mn neurotoxicity are still being elucidated. Aim: The review will highlight a potential role for calcium signaling molecules in the mechanisms of Mn neurotoxicity. Conclusion: Ca2+ regulation influences the neurodegenerative process and there is possible role for perturbed calcium signaling in Mn neurotoxicity. Mechanisms implicated in Mn-induced neurodegeneration include oxidative stress, generation of free radicals, and apoptosis. These are influenced by mitochondrial integrity which can be dependent on intracellular Ca2+ homeostasis. Nevertheless, further elucidation of the direct effects of calcium signaling dysfunction and calcium-binding proteins activities in Mn neurotoxicity is required.

Original languageEnglish (US)
Pages (from-to)146-155
Number of pages10
JournalJournal of Trace Elements in Medicine and Biology
Volume56
DOIs
StatePublished - Dec 1 2019

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Calcium Signaling
Manganese
Calcium
Brain
Neurodegenerative diseases
Molecules
Calcium-Binding Proteins
Oxidative stress
Parkinsonian Disorders
Cellular Structures
Workplace
Neurodegenerative Diseases
Cholinergic Agents
Nervous System
Free Radicals
Neurotransmitter Agents
Parkinson Disease
Hazards
Alzheimer Disease
Oxidative Stress

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Inorganic Chemistry

Cite this

Role for calcium signaling in manganese neurotoxicity. / Ijomone, Omamuyovwi M.; Aluko, Oritoke M.; Okoh, Comfort O.A.; Martins, Airton Cunha; Aschner, Michael.

In: Journal of Trace Elements in Medicine and Biology, Vol. 56, 01.12.2019, p. 146-155.

Research output: Contribution to journalReview article

Ijomone, Omamuyovwi M. ; Aluko, Oritoke M. ; Okoh, Comfort O.A. ; Martins, Airton Cunha ; Aschner, Michael. / Role for calcium signaling in manganese neurotoxicity. In: Journal of Trace Elements in Medicine and Biology. 2019 ; Vol. 56. pp. 146-155.
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