RNA recognition

towards identifying determinants of specificity

Daniel J. Kenan, Charles C. Query, Jack D. Keene

Research output: Contribution to journalArticle

587 Citations (Scopus)

Abstract

Members of a family of proteins containing a conserved ∼80-amino acid RNA recognition motif (RRM) bind specifically to a wide variety of RNA molecules. Structural studies, in combination with sequence alignments, indicate the structural context of both conserved and non-conserved elements in the motif. These analyses suggest that all RRM proteins share a common fold and a similar protein-RNA interface, and that non-conserved residues contribute additional contacts for sequence-specific RNA recognition.

Original languageEnglish (US)
Pages (from-to)214-220
Number of pages7
JournalTrends in Biochemical Sciences
Volume16
Issue numberC
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

RNA
Sequence Alignment
Proteins
Amino Acids
Molecules
RNA Recognition Motif Proteins
RNA Recognition Motif

ASJC Scopus subject areas

  • Biochemistry

Cite this

RNA recognition : towards identifying determinants of specificity. / Kenan, Daniel J.; Query, Charles C.; Keene, Jack D.

In: Trends in Biochemical Sciences, Vol. 16, No. C, 1991, p. 214-220.

Research output: Contribution to journalArticle

Kenan, Daniel J. ; Query, Charles C. ; Keene, Jack D. / RNA recognition : towards identifying determinants of specificity. In: Trends in Biochemical Sciences. 1991 ; Vol. 16, No. C. pp. 214-220.
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