RNA recognition: towards identifying determinants of specificity

Daniel J. Kenan, Charles C. Query, Jack D. Keene

Research output: Contribution to journalArticle

607 Scopus citations

Abstract

Members of a family of proteins containing a conserved ∼80-amino acid RNA recognition motif (RRM) bind specifically to a wide variety of RNA molecules. Structural studies, in combination with sequence alignments, indicate the structural context of both conserved and non-conserved elements in the motif. These analyses suggest that all RRM proteins share a common fold and a similar protein-RNA interface, and that non-conserved residues contribute additional contacts for sequence-specific RNA recognition.

Original languageEnglish (US)
Pages (from-to)214-220
Number of pages7
JournalTrends in Biochemical Sciences
Volume16
Issue numberC
DOIs
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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