Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake

Pooled analysis of prospective cohort studies

Xuehong Zhang, Demetrius Albanes, W. Lawrence Beeson, Piet A. Van Den Brandt, Julie E. Buring, Andrew Flood, Jo L. Freudenheim, Edward L. Giovannucci, R. Alexandra Goldbohm, Karen Jaceldo-Siegl, Eric J. Jacobs, Vittorio Krogh, Susanna C. Larsson, James R. Marshall, Marjorie L. McCullough, Anthony B. Miller, Kim Robien, Thomas E. Rohan, Arthur Schatzkin, Sabina Sieri & 6 others Donna Spiegelman, Jarmo Virtamo, Alicja Wolk, Walter C. Willett, Shumin M. Zhang, Stephanie A. Smith-Warner

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Abstract

BackgroundThe relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved. MethodsWe investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. ResultsCompared with nonconsumers, the pooled multivariable relative risks were 1.07 (95% CI = 0.89 to 1.30, Ptrend =. 68) for coffee consumption greater than 1400 g/d (about six 8-oz cups) and 1.28 (95% CI = 1.02 to 1.61, Ptrend =. 01) for tea consumption greater than 900 g/d (about four 8-oz cups). For sugar-sweetened carbonated soft drink consumption, the pooled multivariable relative risk comparing consumption greater than 550 g/d (about 18 oz) to nonconsumers was 0.94 (95% CI = 0.66 to 1.32, Ptrend =. 91). No statistically significant between-studies heterogeneity was observed for the highest category of each beverage consumed (P >. 20). The observed associations did not differ by sex, smoking status, alcohol consumption, body mass index, physical activity, or tumor site (P >. 05). ConclusionsDrinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk. However, a modest positive association with higher tea consumption is possible and requires further study. The Author 2010. Published by Oxford University Press.

Original languageEnglish (US)
Pages (from-to)771-783
Number of pages13
JournalJournal of the National Cancer Institute
Volume102
Issue number11
DOIs
StatePublished - Jun 2010

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Carbonated Beverages
Coffee
Tea
Colonic Neoplasms
Cohort Studies
Prospective Studies
Confidence Intervals
Beverages
Proportional Hazards Models
Alcohol Drinking
Body Mass Index
Smoking
Exercise

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Zhang, X., Albanes, D., Beeson, W. L., Van Den Brandt, P. A., Buring, J. E., Flood, A., ... Smith-Warner, S. A. (2010). Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: Pooled analysis of prospective cohort studies. Journal of the National Cancer Institute, 102(11), 771-783. https://doi.org/10.1093/jnci/djq107

Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake : Pooled analysis of prospective cohort studies. / Zhang, Xuehong; Albanes, Demetrius; Beeson, W. Lawrence; Van Den Brandt, Piet A.; Buring, Julie E.; Flood, Andrew; Freudenheim, Jo L.; Giovannucci, Edward L.; Goldbohm, R. Alexandra; Jaceldo-Siegl, Karen; Jacobs, Eric J.; Krogh, Vittorio; Larsson, Susanna C.; Marshall, James R.; McCullough, Marjorie L.; Miller, Anthony B.; Robien, Kim; Rohan, Thomas E.; Schatzkin, Arthur; Sieri, Sabina; Spiegelman, Donna; Virtamo, Jarmo; Wolk, Alicja; Willett, Walter C.; Zhang, Shumin M.; Smith-Warner, Stephanie A.

In: Journal of the National Cancer Institute, Vol. 102, No. 11, 06.2010, p. 771-783.

Research output: Contribution to journalArticle

Zhang, X, Albanes, D, Beeson, WL, Van Den Brandt, PA, Buring, JE, Flood, A, Freudenheim, JL, Giovannucci, EL, Goldbohm, RA, Jaceldo-Siegl, K, Jacobs, EJ, Krogh, V, Larsson, SC, Marshall, JR, McCullough, ML, Miller, AB, Robien, K, Rohan, TE, Schatzkin, A, Sieri, S, Spiegelman, D, Virtamo, J, Wolk, A, Willett, WC, Zhang, SM & Smith-Warner, SA 2010, 'Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: Pooled analysis of prospective cohort studies', Journal of the National Cancer Institute, vol. 102, no. 11, pp. 771-783. https://doi.org/10.1093/jnci/djq107
Zhang, Xuehong ; Albanes, Demetrius ; Beeson, W. Lawrence ; Van Den Brandt, Piet A. ; Buring, Julie E. ; Flood, Andrew ; Freudenheim, Jo L. ; Giovannucci, Edward L. ; Goldbohm, R. Alexandra ; Jaceldo-Siegl, Karen ; Jacobs, Eric J. ; Krogh, Vittorio ; Larsson, Susanna C. ; Marshall, James R. ; McCullough, Marjorie L. ; Miller, Anthony B. ; Robien, Kim ; Rohan, Thomas E. ; Schatzkin, Arthur ; Sieri, Sabina ; Spiegelman, Donna ; Virtamo, Jarmo ; Wolk, Alicja ; Willett, Walter C. ; Zhang, Shumin M. ; Smith-Warner, Stephanie A. / Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake : Pooled analysis of prospective cohort studies. In: Journal of the National Cancer Institute. 2010 ; Vol. 102, No. 11. pp. 771-783.
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abstract = "BackgroundThe relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved. MethodsWe investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95{\%} confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. ResultsCompared with nonconsumers, the pooled multivariable relative risks were 1.07 (95{\%} CI = 0.89 to 1.30, Ptrend =. 68) for coffee consumption greater than 1400 g/d (about six 8-oz cups) and 1.28 (95{\%} CI = 1.02 to 1.61, Ptrend =. 01) for tea consumption greater than 900 g/d (about four 8-oz cups). For sugar-sweetened carbonated soft drink consumption, the pooled multivariable relative risk comparing consumption greater than 550 g/d (about 18 oz) to nonconsumers was 0.94 (95{\%} CI = 0.66 to 1.32, Ptrend =. 91). No statistically significant between-studies heterogeneity was observed for the highest category of each beverage consumed (P >. 20). The observed associations did not differ by sex, smoking status, alcohol consumption, body mass index, physical activity, or tumor site (P >. 05). ConclusionsDrinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk. However, a modest positive association with higher tea consumption is possible and requires further study. The Author 2010. Published by Oxford University Press.",
author = "Xuehong Zhang and Demetrius Albanes and Beeson, {W. Lawrence} and {Van Den Brandt}, {Piet A.} and Buring, {Julie E.} and Andrew Flood and Freudenheim, {Jo L.} and Giovannucci, {Edward L.} and Goldbohm, {R. Alexandra} and Karen Jaceldo-Siegl and Jacobs, {Eric J.} and Vittorio Krogh and Larsson, {Susanna C.} and Marshall, {James R.} and McCullough, {Marjorie L.} and Miller, {Anthony B.} and Kim Robien and Rohan, {Thomas E.} and Arthur Schatzkin and Sabina Sieri and Donna Spiegelman and Jarmo Virtamo and Alicja Wolk and Willett, {Walter C.} and Zhang, {Shumin M.} and Smith-Warner, {Stephanie A.}",
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TY - JOUR

T1 - Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake

T2 - Pooled analysis of prospective cohort studies

AU - Zhang, Xuehong

AU - Albanes, Demetrius

AU - Beeson, W. Lawrence

AU - Van Den Brandt, Piet A.

AU - Buring, Julie E.

AU - Flood, Andrew

AU - Freudenheim, Jo L.

AU - Giovannucci, Edward L.

AU - Goldbohm, R. Alexandra

AU - Jaceldo-Siegl, Karen

AU - Jacobs, Eric J.

AU - Krogh, Vittorio

AU - Larsson, Susanna C.

AU - Marshall, James R.

AU - McCullough, Marjorie L.

AU - Miller, Anthony B.

AU - Robien, Kim

AU - Rohan, Thomas E.

AU - Schatzkin, Arthur

AU - Sieri, Sabina

AU - Spiegelman, Donna

AU - Virtamo, Jarmo

AU - Wolk, Alicja

AU - Willett, Walter C.

AU - Zhang, Shumin M.

AU - Smith-Warner, Stephanie A.

PY - 2010/6

Y1 - 2010/6

N2 - BackgroundThe relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved. MethodsWe investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. ResultsCompared with nonconsumers, the pooled multivariable relative risks were 1.07 (95% CI = 0.89 to 1.30, Ptrend =. 68) for coffee consumption greater than 1400 g/d (about six 8-oz cups) and 1.28 (95% CI = 1.02 to 1.61, Ptrend =. 01) for tea consumption greater than 900 g/d (about four 8-oz cups). For sugar-sweetened carbonated soft drink consumption, the pooled multivariable relative risk comparing consumption greater than 550 g/d (about 18 oz) to nonconsumers was 0.94 (95% CI = 0.66 to 1.32, Ptrend =. 91). No statistically significant between-studies heterogeneity was observed for the highest category of each beverage consumed (P >. 20). The observed associations did not differ by sex, smoking status, alcohol consumption, body mass index, physical activity, or tumor site (P >. 05). ConclusionsDrinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk. However, a modest positive association with higher tea consumption is possible and requires further study. The Author 2010. Published by Oxford University Press.

AB - BackgroundThe relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved. MethodsWe investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. ResultsCompared with nonconsumers, the pooled multivariable relative risks were 1.07 (95% CI = 0.89 to 1.30, Ptrend =. 68) for coffee consumption greater than 1400 g/d (about six 8-oz cups) and 1.28 (95% CI = 1.02 to 1.61, Ptrend =. 01) for tea consumption greater than 900 g/d (about four 8-oz cups). For sugar-sweetened carbonated soft drink consumption, the pooled multivariable relative risk comparing consumption greater than 550 g/d (about 18 oz) to nonconsumers was 0.94 (95% CI = 0.66 to 1.32, Ptrend =. 91). No statistically significant between-studies heterogeneity was observed for the highest category of each beverage consumed (P >. 20). The observed associations did not differ by sex, smoking status, alcohol consumption, body mass index, physical activity, or tumor site (P >. 05). ConclusionsDrinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk. However, a modest positive association with higher tea consumption is possible and requires further study. The Author 2010. Published by Oxford University Press.

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U2 - 10.1093/jnci/djq107

DO - 10.1093/jnci/djq107

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