Rigorous pre-clinical evaluation of topical microbicides to prevent transmission of human immunodeficiency virus

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

In summary, more extensive pre-clinical evaluation of SAMMA and other microbicides in development is required. The activity against primary isolates in the presence of genital tract fluids and over a broad pH range should be carefully evaluated. Optimization of formulations will require more attention. Formulation characteristics affecting microbicide efficacy include hydrophilicity, dispersibility, viscosity and bioadhesion. Development and standardization of human explant cultures and animal models to test the efficacy and safety of formulated compounds is essential. Pilot in vivo studies focusing on a thorough investigation of the changes in inflammatory cells and cytokines following topical application of candidate agents are recommended before the initiation of large-scale clinical trials.

Original languageEnglish (US)
Pages (from-to)1099-1102
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume51
Issue number5
DOIs
StatePublished - May 1 2003
Externally publishedYes

Keywords

  • HIV
  • Microbicides

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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