Right-sided ectocervical lesions may be associated with false-negative cytology among women with histologic cervical intraepithelial neoplasia 2 or 3

Jose Jeronimo, Philip E. Castle, Rolando Herrero, Mark E. Sherman, M. Concepcion Bratti, Allan Hildesheim, Mario Alfaro, Jorge Morales, Martha L. Hutchinson, Robert D. Burk, Attila Lorincz, Sholom Wacholder, Ana Cecilia Rodríguez, Mark Schiffman

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background. The association between the location of an ectocervical lesion and the sensibility of cytologic screening has not been adequately evaluated. Methods. We evaluated the proportion of false-negative cytologic interpretations using three independent cytologic interpretations (conventional, PapNet, and ThinPrep) according to lesion location in 111 women with histologic cervical intraepithelial neoplasia 2 or 3 of a population-based study of cervical neoplasia conducted in Guanacaste, Costa Rica. Semiquantitative measures of human papillomavirus viral load were also considered. Results. Lesions on a women's right ectocervix were associated with more frequent false-negative results than lesions on left ectocervix for each of the cytologic methods or when the most severe interpretation was considered (p = .004). Right-sided lesions had nonsignificantly lower viral loads than left-sided lesions (p = .2). Conclusions. Cervical intraepithelial neoplasia 2 or 3 located on the right side of the cervix may be poorly sampled with broom samplers in some settings, resulting in false-negative cytologic results.

Original languageEnglish (US)
Pages (from-to)175-183
Number of pages9
JournalJournal of Lower Genital Tract Disease
Volume7
Issue number3
DOIs
StatePublished - Jul 2003

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Cervical Intraepithelial Neoplasia
Viral Load
Cell Biology
Costa Rica
Women's Rights
Cervix Uteri
Population
Neoplasms

Keywords

  • Cervical intraepithelial neoplasia
  • Cervix
  • Cytology
  • False negative
  • Human papillomavirus

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Right-sided ectocervical lesions may be associated with false-negative cytology among women with histologic cervical intraepithelial neoplasia 2 or 3. / Jeronimo, Jose; Castle, Philip E.; Herrero, Rolando; Sherman, Mark E.; Bratti, M. Concepcion; Hildesheim, Allan; Alfaro, Mario; Morales, Jorge; Hutchinson, Martha L.; Burk, Robert D.; Lorincz, Attila; Wacholder, Sholom; Rodríguez, Ana Cecilia; Schiffman, Mark.

In: Journal of Lower Genital Tract Disease, Vol. 7, No. 3, 07.2003, p. 175-183.

Research output: Contribution to journalArticle

Jeronimo, J, Castle, PE, Herrero, R, Sherman, ME, Bratti, MC, Hildesheim, A, Alfaro, M, Morales, J, Hutchinson, ML, Burk, RD, Lorincz, A, Wacholder, S, Rodríguez, AC & Schiffman, M 2003, 'Right-sided ectocervical lesions may be associated with false-negative cytology among women with histologic cervical intraepithelial neoplasia 2 or 3', Journal of Lower Genital Tract Disease, vol. 7, no. 3, pp. 175-183. https://doi.org/10.1097/00128360-200307000-00004
Jeronimo, Jose ; Castle, Philip E. ; Herrero, Rolando ; Sherman, Mark E. ; Bratti, M. Concepcion ; Hildesheim, Allan ; Alfaro, Mario ; Morales, Jorge ; Hutchinson, Martha L. ; Burk, Robert D. ; Lorincz, Attila ; Wacholder, Sholom ; Rodríguez, Ana Cecilia ; Schiffman, Mark. / Right-sided ectocervical lesions may be associated with false-negative cytology among women with histologic cervical intraepithelial neoplasia 2 or 3. In: Journal of Lower Genital Tract Disease. 2003 ; Vol. 7, No. 3. pp. 175-183.
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AU - Castle, Philip E.

AU - Herrero, Rolando

AU - Sherman, Mark E.

AU - Bratti, M. Concepcion

AU - Hildesheim, Allan

AU - Alfaro, Mario

AU - Morales, Jorge

AU - Hutchinson, Martha L.

AU - Burk, Robert D.

AU - Lorincz, Attila

AU - Wacholder, Sholom

AU - Rodríguez, Ana Cecilia

AU - Schiffman, Mark

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N2 - Background. The association between the location of an ectocervical lesion and the sensibility of cytologic screening has not been adequately evaluated. Methods. We evaluated the proportion of false-negative cytologic interpretations using three independent cytologic interpretations (conventional, PapNet, and ThinPrep) according to lesion location in 111 women with histologic cervical intraepithelial neoplasia 2 or 3 of a population-based study of cervical neoplasia conducted in Guanacaste, Costa Rica. Semiquantitative measures of human papillomavirus viral load were also considered. Results. Lesions on a women's right ectocervix were associated with more frequent false-negative results than lesions on left ectocervix for each of the cytologic methods or when the most severe interpretation was considered (p = .004). Right-sided lesions had nonsignificantly lower viral loads than left-sided lesions (p = .2). Conclusions. Cervical intraepithelial neoplasia 2 or 3 located on the right side of the cervix may be poorly sampled with broom samplers in some settings, resulting in false-negative cytologic results.

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