Ribosome assisted protein folding: Some of its biological implications

Dibyendu Samanta, Anindita Das, Debasis Das, Arpita Bhattacharya, Arunima Basu, Jaydip Ghosh, Chanchal Dasgupta

Research output: Contribution to journalArticlepeer-review


One of the central characteristics of a living system is the ability to self-assemble its component molecular structures with precision and fidelity. The folding of proteins into their compact three-dimensional structures is the most fundamental and universal example of biological self-assembly. Understanding this complex process will therefore make available a unique insight into the way in which evolutionary selection has influenced the properties of a molecular system for functional advantage. The final goal of folding studies is to predict structure from sequence, allowing the design of new functional proteins and prevention of abnormal disease-associated protein conformations.

Original languageEnglish (US)
Pages (from-to)223-246
Number of pages24
JournalProteomics Research Journal
Issue number3-4
StatePublished - Dec 1 2010

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology


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