Rheumatic manifestations of euthyroid, anti-thyroid antibody-positive patients

Clement E. Tagoe, Anna Zezon, Saakshi Khattri, Patricia Castellanos

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The aim of this study is to define the rheumatic manifestations of euthyroid patients with chronic lymphocytic thyroiditis (CLT) but without a well-defined connective tissue disease. Forty-six consecutive patients with anti-thyroid peroxidase (αTPO) and/or anti-thyroglobulin antibodies (αTG), and normal thyroid function in the absence of a well-defined connective tissue disease were included in a case-cohort study. Arthralgias were a presenting complaint in 98 % of patients. Fibromyalgia syndrome was found in 59 % of patients. Raynaud's phenomenon occurred in 28 % and sicca symptoms in 26 % of patients. Two patients had seronegative arthritis resembling rheumatoid arthritis. Arthritis was radiographically present in 88 %, affecting the spine in 45 % of patients. Thyroid-stimulating hormone (TSH) levels positively correlated with levels of αTPO, but not with erythrocyte sedimentation rate (ESR) or αTG levels. A positive ANA was found in 24 % of patients. One patient developed subclinical hypothyroidism during the study. Rheumatic manifestations frequently occur in patients with CLT in the absence of overt thyroid dysfunction and mimic the presentation of the well-defined connective tissue diseases.

Original languageEnglish (US)
Pages (from-to)1745-1752
Number of pages8
JournalRheumatology International
Volume33
Issue number7
DOIs
StatePublished - Jul 2013

Fingerprint

Anti-Idiotypic Antibodies
Thyroid Gland
Connective Tissue Diseases
Iodide Peroxidase
Hashimoto Disease
Arthritis
Raynaud Disease
Fibromyalgia
Thyroglobulin
Blood Sedimentation
Arthralgia
Thyrotropin
Hypothyroidism
Rheumatoid Arthritis
Spine
Cohort Studies
Antibodies

Keywords

  • Arthritis
  • Autoimmune thyroid disease
  • Chronic lymphocytic thyroiditis
  • Fibromyalgia
  • Hashimoto thyroiditis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Rheumatic manifestations of euthyroid, anti-thyroid antibody-positive patients. / Tagoe, Clement E.; Zezon, Anna; Khattri, Saakshi; Castellanos, Patricia.

In: Rheumatology International, Vol. 33, No. 7, 07.2013, p. 1745-1752.

Research output: Contribution to journalArticle

Tagoe, Clement E. ; Zezon, Anna ; Khattri, Saakshi ; Castellanos, Patricia. / Rheumatic manifestations of euthyroid, anti-thyroid antibody-positive patients. In: Rheumatology International. 2013 ; Vol. 33, No. 7. pp. 1745-1752.
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