Rhabdomyolysis: An unusual complication of cytotoxic chemotherapy

Robert J. Levy, Joseph A. Sparano, Ghazali Khan

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Acute rhabdomyolysis has rarely been reported after cytotoxic chemotherapy, including cytarabine and 5-azacytidine. We observed a case of acute rhabdomyolysis and renal failure after treatment with mitoxantrone and cyclophosphamide. No other cause of muscle injury could be identified, although biochemical analysis of a muscle biopsy specimen revealed a deficiency of muscle phosphorylase activity. Retreatment with doxorubicin and paclitaxel was not associated with recurrent rhabdomyolysis.

Original languageEnglish (US)
Pages (from-to)219-222
Number of pages4
JournalMedical Oncology
Volume12
Issue number4
DOIs
StatePublished - Dec 1995

Fingerprint

Rhabdomyolysis
Drug Therapy
Glycogen Storage Disease Type V
Azacitidine
Muscles
Mitoxantrone
Retreatment
Cytarabine
Paclitaxel
Acute Kidney Injury
Doxorubicin
Cyclophosphamide
Biopsy
Wounds and Injuries
Therapeutics

Keywords

  • acute rhabdomyolysis
  • chemotherapy
  • cyclophosphamide
  • mitoxantrone
  • phosphorylase deficiency

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Rhabdomyolysis : An unusual complication of cytotoxic chemotherapy. / Levy, Robert J.; Sparano, Joseph A.; Khan, Ghazali.

In: Medical Oncology, Vol. 12, No. 4, 12.1995, p. 219-222.

Research output: Contribution to journalArticle

Levy, Robert J. ; Sparano, Joseph A. ; Khan, Ghazali. / Rhabdomyolysis : An unusual complication of cytotoxic chemotherapy. In: Medical Oncology. 1995 ; Vol. 12, No. 4. pp. 219-222.
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