Review: Molecular mechanism of microglia stimulated glioblastoma invasion

Salvatore J. Coniglio; Jeffrey E. Segall

doi:10.1016/j.matbio.2013.07.008

Review: Molecular mechanism of microglia stimulated glioblastoma invasion

Salvatore J. Coniglio, Jeffrey E. Segall

Pathology

Research output: Contribution to journal › Review article › peer-review

84 Scopus citations

Abstract

Glioblastoma multiforme is one of the deadliest human cancers and is characterized by a high degree of microglia and macrophage infiltration. The role of these glioma infiltrating macrophages (GIMs) in disease progression has been the subject of recent investigation. While initially thought to reflect an immune response to the tumor, the balance of evidence clearly suggests GIMs can have potent tumor-tropic functions and assist in glioma cell growth and infiltration into normal brain. In this review, we focus on the evidence for GIMs aiding mediating glioblastoma motility and invasion. We survey the literature for molecular pathways that are involved in paracrine interaction between glioma cells and GIMs and assess which of these might serve as attractive targets for therapeutic intervention.

Original language	English (US)
Pages (from-to)	372-380
Number of pages	9
Journal	Matrix Biology
Volume	32
Issue number	7-8
DOIs	https://doi.org/10.1016/j.matbio.2013.07.008
State	Published - Oct 2013

Keywords

CSF-1R
Glioma
Invasion
MMPs
Macrophages
Microglia
TGFβ

ASJC Scopus subject areas

Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.matbio.2013.07.008

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title = "Review: Molecular mechanism of microglia stimulated glioblastoma invasion",

abstract = "Glioblastoma multiforme is one of the deadliest human cancers and is characterized by a high degree of microglia and macrophage infiltration. The role of these glioma infiltrating macrophages (GIMs) in disease progression has been the subject of recent investigation. While initially thought to reflect an immune response to the tumor, the balance of evidence clearly suggests GIMs can have potent tumor-tropic functions and assist in glioma cell growth and infiltration into normal brain. In this review, we focus on the evidence for GIMs aiding mediating glioblastoma motility and invasion. We survey the literature for molecular pathways that are involved in paracrine interaction between glioma cells and GIMs and assess which of these might serve as attractive targets for therapeutic intervention.",

keywords = "CSF-1R, Glioma, Invasion, MMPs, Macrophages, Microglia, TGFβ",

author = "Coniglio, {Salvatore J.} and Segall, {Jeffrey E.}",

note = "Funding Information: We thank Dr. Amanda Chan and Jeffrey Wyckoff for producing Fig. 1 . We would also like to thank our colleagues in the Segall laboratory and faculty of the Department of Anatomy and Structural Biology for helpful discussions. Our research cited in this review was funded by the AICR , American Cancer Society , and CA100324 .",

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doi = "10.1016/j.matbio.2013.07.008",

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AU - Coniglio, Salvatore J.

AU - Segall, Jeffrey E.

N1 - Funding Information: We thank Dr. Amanda Chan and Jeffrey Wyckoff for producing Fig. 1 . We would also like to thank our colleagues in the Segall laboratory and faculty of the Department of Anatomy and Structural Biology for helpful discussions. Our research cited in this review was funded by the AICR , American Cancer Society , and CA100324 .

PY - 2013/10

Y1 - 2013/10

N2 - Glioblastoma multiforme is one of the deadliest human cancers and is characterized by a high degree of microglia and macrophage infiltration. The role of these glioma infiltrating macrophages (GIMs) in disease progression has been the subject of recent investigation. While initially thought to reflect an immune response to the tumor, the balance of evidence clearly suggests GIMs can have potent tumor-tropic functions and assist in glioma cell growth and infiltration into normal brain. In this review, we focus on the evidence for GIMs aiding mediating glioblastoma motility and invasion. We survey the literature for molecular pathways that are involved in paracrine interaction between glioma cells and GIMs and assess which of these might serve as attractive targets for therapeutic intervention.

AB - Glioblastoma multiforme is one of the deadliest human cancers and is characterized by a high degree of microglia and macrophage infiltration. The role of these glioma infiltrating macrophages (GIMs) in disease progression has been the subject of recent investigation. While initially thought to reflect an immune response to the tumor, the balance of evidence clearly suggests GIMs can have potent tumor-tropic functions and assist in glioma cell growth and infiltration into normal brain. In this review, we focus on the evidence for GIMs aiding mediating glioblastoma motility and invasion. We survey the literature for molecular pathways that are involved in paracrine interaction between glioma cells and GIMs and assess which of these might serve as attractive targets for therapeutic intervention.

KW - CSF-1R

KW - Glioma

KW - Invasion

KW - MMPs

KW - Macrophages

KW - Microglia

KW - TGFβ

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DO - 10.1016/j.matbio.2013.07.008

M3 - Review article

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JO - Matrix Biology

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ER -

Review: Molecular mechanism of microglia stimulated glioblastoma invasion

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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