Review: Molecular mechanism of microglia stimulated glioblastoma invasion

Salvatore J. Coniglio, Jeffrey E. Segall

Research output: Contribution to journalReview article

57 Scopus citations

Abstract

Glioblastoma multiforme is one of the deadliest human cancers and is characterized by a high degree of microglia and macrophage infiltration. The role of these glioma infiltrating macrophages (GIMs) in disease progression has been the subject of recent investigation. While initially thought to reflect an immune response to the tumor, the balance of evidence clearly suggests GIMs can have potent tumor-tropic functions and assist in glioma cell growth and infiltration into normal brain. In this review, we focus on the evidence for GIMs aiding mediating glioblastoma motility and invasion. We survey the literature for molecular pathways that are involved in paracrine interaction between glioma cells and GIMs and assess which of these might serve as attractive targets for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)372-380
Number of pages9
JournalMatrix Biology
Volume32
Issue number7-8
DOIs
StatePublished - Oct 1 2013

Keywords

  • CSF-1R
  • Glioma
  • Invasion
  • MMPs
  • Macrophages
  • Microglia
  • TGFβ

ASJC Scopus subject areas

  • Molecular Biology

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