Retinoic acid suppresses intimal hyperplasia and prevents vessel remodeling following arterial injury

Joseph DeRose, J. Madigan, J. P. Umana, J. H. Prystowsky, R. Nowygrod, M. C. Oz, G. J. Todd

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Vitamin A and its derivatives (retinoids) are capable of inhibiting vascular smooth muscle cell proliferation in vitro. The present study examines the effect of two retinoids, all-trans retinoic acid and 13-cis retinoic acid, on intimal hyperplasia following arterial injury. After receiving varying doses of all-trans retinoic acid or 13-cis retinoic acid, 78 male Sprague-Dawley rats underwent standard balloon catheter denudation of the left common carotid artery. Morphometric analysis and immunohistochemistry for proliferating cell nuclear antigen was performed at early and late time points. Intimal/medial ratios were reduced in a dose-dependent fashion for animals treated with all-trans retinoic acid (P=0.001) and 13-cis retinoic acid (P=0.004). Proliferating cell nuclear antigen labeling indices were reduced after treatment with all-trans retinoic acid and 13-cis retinoic acid at early time points post-injury. At a dose of 10mg/kg, both all-trans retinoic acid and 13-cis retinoic acid inhibited vessel remodeling as measured by increases in luminal diameter (P<0.05) and external elastic lamina (P<0.05). Retinoids are an attractive clinical option for the treatment of restenosis following angioplasty and arterial surgery. Copyright (C) 1999 The International Society for Cardiovascular Surgery.

Original languageEnglish (US)
Pages (from-to)633-639
Number of pages7
JournalCardiovascular Surgery
Volume7
Issue number6
DOIs
StatePublished - Oct 1999
Externally publishedYes

Fingerprint

Tunica Intima
Isotretinoin
Tretinoin
Hyperplasia
Retinoids
Wounds and Injuries
Proliferating Cell Nuclear Antigen
Common Carotid Artery
Vitamin A
Vascular Smooth Muscle
Angioplasty
Smooth Muscle Myocytes
Sprague Dawley Rats
Catheters
Immunohistochemistry
Cell Proliferation
Therapeutics

Keywords

  • Intimal hyperplasia
  • Restenosis
  • Retinoic acid

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

Cite this

Retinoic acid suppresses intimal hyperplasia and prevents vessel remodeling following arterial injury. / DeRose, Joseph; Madigan, J.; Umana, J. P.; Prystowsky, J. H.; Nowygrod, R.; Oz, M. C.; Todd, G. J.

In: Cardiovascular Surgery, Vol. 7, No. 6, 10.1999, p. 633-639.

Research output: Contribution to journalArticle

DeRose, Joseph ; Madigan, J. ; Umana, J. P. ; Prystowsky, J. H. ; Nowygrod, R. ; Oz, M. C. ; Todd, G. J. / Retinoic acid suppresses intimal hyperplasia and prevents vessel remodeling following arterial injury. In: Cardiovascular Surgery. 1999 ; Vol. 7, No. 6. pp. 633-639.
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