Retinoic acid signaling in mammalian eye development

Ales Cvekl, Wei Lin Wang

Research output: Contribution to journalReview article

89 Scopus citations

Abstract

Retinoic acid (RA) is a biologically active metabolite of vitamin A (retinol) that serves as a signaling molecule during a number of developmental and physiological processes. RA signaling plays multiple roles during embryonic eye development. RA signaling is initially required for reciprocal interactions between the optic vesicle and invaginating lens placode. RA signaling promotes normal development of the ventral retina and optic nerve through its activities in the neural crest cell-derived periocular mesenchyme. RA coordinates these processes by regulating biological activities of a family of non-steroid hormone receptors, RARα/β/γ, and RXRα/β/γ. These DNA-binding transcription factors recognize DNA as RAR/RXR heterodimers and recruit multiprotein transcriptional co-repressor complexes. RA-binding to RAR receptors induces a conformational change in the receptor, followed by the replacement of co-repressor with co-activator complexes. Inactivation of RARα/β/γ receptors in the periocular mesenchyme abrogates anterior eye segment formation. This review summarizes recent genetic studies of RA signaling and progress in understanding the molecular mechanism of transcriptional co-activators that function with RAR/RXR.

Original languageEnglish (US)
Pages (from-to)280-291
Number of pages12
JournalExperimental Eye Research
Volume89
Issue number3
DOIs
StatePublished - Sep 1 2009

Keywords

  • anterior segment
  • lens
  • nuclear receptors
  • optic cup
  • periocular mesenchyme
  • retina
  • retinoic acid
  • vitamin A

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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