Responses of Mycobacterium tuberculosis to growth in the mouse lung

Eugenie Dubnau, John Chan, V. P. Mohan, Issar Smith

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Using a promoter trap, we have identified 56 Mycobacterium tuberculosis genes preferentially expressed in the mouse lung. Quantitative real-time PCR showed that RNA levels of several genes were higher from bacteria growing in mouse lungs than from broth cultures. These results support the current hypothesis that Mycobacterium tuberculosis utilizes fatty acids as a carbon source in the mouse lung.

Original languageEnglish (US)
Pages (from-to)3754-3757
Number of pages4
JournalInfection and Immunity
Volume73
Issue number6
DOIs
StatePublished - Jun 2005

Fingerprint

Mycobacterium tuberculosis
Lung
Growth
Genes
Real-Time Polymerase Chain Reaction
Fatty Acids
Carbon
RNA
Bacteria

ASJC Scopus subject areas

  • Immunology

Cite this

Responses of Mycobacterium tuberculosis to growth in the mouse lung. / Dubnau, Eugenie; Chan, John; Mohan, V. P.; Smith, Issar.

In: Infection and Immunity, Vol. 73, No. 6, 06.2005, p. 3754-3757.

Research output: Contribution to journalArticle

Dubnau, Eugenie ; Chan, John ; Mohan, V. P. ; Smith, Issar. / Responses of Mycobacterium tuberculosis to growth in the mouse lung. In: Infection and Immunity. 2005 ; Vol. 73, No. 6. pp. 3754-3757.
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