Respiratory illness and hypophosphatemia

John Devens Fisher, N. Magid, C. Kallman, M. Fanucchi, L. Klein, D. McCarthy, I. Roberts, G. Schulman

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

We retrospectively reviewed the charts of 308 admissions to a pulmonary disease ward and 100 admissions to the general medical service over one year to find the prevalence, sequelae, and etiology of hypophosphatemia. The overall prevalence of low serum phosphate levels (<2.4 mg/dl) occurring at least once during hospitalization in chest patients was 17 percent, but was higher in patients with respiratory infections (28 percent). Moreover, the prevalence of hypophosphatemia on admission (before institution of intravenous fluid or drug therapy) was ten times higher in patients with respiratory infections than in patients with noninfectious respiratory illness or general medical patients (21 vs 2 percent, p < 0.001). Serum phosphate <2.0 mg/dl occurred in 4 percent of patients. Twenty-seven percent of the patients (including two with ventilatory failure) with abnormally low serum phosphate levels had symptoms or signs of uncertain etiology later explicable by the presence of hypophosphatemia. The most common additional laboratory finding associated with hypophosphatemia was elevation of muscle enzymes. Although mortality was no higher in hypophosphatemic patients, hospital stay was twice as long as that of patients with normal levels of serum phosphate. No correlation was found between simultaneous arterial blood gases and serum phosphate levels. Two patients given antacids had severe hypophosphatemia and worsened ventilatory function; phosphate-binding antacids should be used judiciously in patients with severe respiratory disease, since they may lead to the development or worsening of hypophosphatemia and diminished ventilatory function.

Original languageEnglish (US)
Pages (from-to)504-508
Number of pages5
JournalChest
Volume83
Issue number3
StatePublished - 1983

Fingerprint

Hypophosphatemia
Phosphates
Serum
Antacids
Respiratory Tract Infections
Fluid Therapy
Lung Diseases
Signs and Symptoms
Length of Stay
Hospitalization
Thorax
Gases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Fisher, J. D., Magid, N., Kallman, C., Fanucchi, M., Klein, L., McCarthy, D., ... Schulman, G. (1983). Respiratory illness and hypophosphatemia. Chest, 83(3), 504-508.

Respiratory illness and hypophosphatemia. / Fisher, John Devens; Magid, N.; Kallman, C.; Fanucchi, M.; Klein, L.; McCarthy, D.; Roberts, I.; Schulman, G.

In: Chest, Vol. 83, No. 3, 1983, p. 504-508.

Research output: Contribution to journalArticle

Fisher, JD, Magid, N, Kallman, C, Fanucchi, M, Klein, L, McCarthy, D, Roberts, I & Schulman, G 1983, 'Respiratory illness and hypophosphatemia', Chest, vol. 83, no. 3, pp. 504-508.
Fisher JD, Magid N, Kallman C, Fanucchi M, Klein L, McCarthy D et al. Respiratory illness and hypophosphatemia. Chest. 1983;83(3):504-508.
Fisher, John Devens ; Magid, N. ; Kallman, C. ; Fanucchi, M. ; Klein, L. ; McCarthy, D. ; Roberts, I. ; Schulman, G. / Respiratory illness and hypophosphatemia. In: Chest. 1983 ; Vol. 83, No. 3. pp. 504-508.
@article{58334326e9054173bf58db6359233a62,
title = "Respiratory illness and hypophosphatemia",
abstract = "We retrospectively reviewed the charts of 308 admissions to a pulmonary disease ward and 100 admissions to the general medical service over one year to find the prevalence, sequelae, and etiology of hypophosphatemia. The overall prevalence of low serum phosphate levels (<2.4 mg/dl) occurring at least once during hospitalization in chest patients was 17 percent, but was higher in patients with respiratory infections (28 percent). Moreover, the prevalence of hypophosphatemia on admission (before institution of intravenous fluid or drug therapy) was ten times higher in patients with respiratory infections than in patients with noninfectious respiratory illness or general medical patients (21 vs 2 percent, p < 0.001). Serum phosphate <2.0 mg/dl occurred in 4 percent of patients. Twenty-seven percent of the patients (including two with ventilatory failure) with abnormally low serum phosphate levels had symptoms or signs of uncertain etiology later explicable by the presence of hypophosphatemia. The most common additional laboratory finding associated with hypophosphatemia was elevation of muscle enzymes. Although mortality was no higher in hypophosphatemic patients, hospital stay was twice as long as that of patients with normal levels of serum phosphate. No correlation was found between simultaneous arterial blood gases and serum phosphate levels. Two patients given antacids had severe hypophosphatemia and worsened ventilatory function; phosphate-binding antacids should be used judiciously in patients with severe respiratory disease, since they may lead to the development or worsening of hypophosphatemia and diminished ventilatory function.",
author = "Fisher, {John Devens} and N. Magid and C. Kallman and M. Fanucchi and L. Klein and D. McCarthy and I. Roberts and G. Schulman",
year = "1983",
language = "English (US)",
volume = "83",
pages = "504--508",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "3",

}

TY - JOUR

T1 - Respiratory illness and hypophosphatemia

AU - Fisher, John Devens

AU - Magid, N.

AU - Kallman, C.

AU - Fanucchi, M.

AU - Klein, L.

AU - McCarthy, D.

AU - Roberts, I.

AU - Schulman, G.

PY - 1983

Y1 - 1983

N2 - We retrospectively reviewed the charts of 308 admissions to a pulmonary disease ward and 100 admissions to the general medical service over one year to find the prevalence, sequelae, and etiology of hypophosphatemia. The overall prevalence of low serum phosphate levels (<2.4 mg/dl) occurring at least once during hospitalization in chest patients was 17 percent, but was higher in patients with respiratory infections (28 percent). Moreover, the prevalence of hypophosphatemia on admission (before institution of intravenous fluid or drug therapy) was ten times higher in patients with respiratory infections than in patients with noninfectious respiratory illness or general medical patients (21 vs 2 percent, p < 0.001). Serum phosphate <2.0 mg/dl occurred in 4 percent of patients. Twenty-seven percent of the patients (including two with ventilatory failure) with abnormally low serum phosphate levels had symptoms or signs of uncertain etiology later explicable by the presence of hypophosphatemia. The most common additional laboratory finding associated with hypophosphatemia was elevation of muscle enzymes. Although mortality was no higher in hypophosphatemic patients, hospital stay was twice as long as that of patients with normal levels of serum phosphate. No correlation was found between simultaneous arterial blood gases and serum phosphate levels. Two patients given antacids had severe hypophosphatemia and worsened ventilatory function; phosphate-binding antacids should be used judiciously in patients with severe respiratory disease, since they may lead to the development or worsening of hypophosphatemia and diminished ventilatory function.

AB - We retrospectively reviewed the charts of 308 admissions to a pulmonary disease ward and 100 admissions to the general medical service over one year to find the prevalence, sequelae, and etiology of hypophosphatemia. The overall prevalence of low serum phosphate levels (<2.4 mg/dl) occurring at least once during hospitalization in chest patients was 17 percent, but was higher in patients with respiratory infections (28 percent). Moreover, the prevalence of hypophosphatemia on admission (before institution of intravenous fluid or drug therapy) was ten times higher in patients with respiratory infections than in patients with noninfectious respiratory illness or general medical patients (21 vs 2 percent, p < 0.001). Serum phosphate <2.0 mg/dl occurred in 4 percent of patients. Twenty-seven percent of the patients (including two with ventilatory failure) with abnormally low serum phosphate levels had symptoms or signs of uncertain etiology later explicable by the presence of hypophosphatemia. The most common additional laboratory finding associated with hypophosphatemia was elevation of muscle enzymes. Although mortality was no higher in hypophosphatemic patients, hospital stay was twice as long as that of patients with normal levels of serum phosphate. No correlation was found between simultaneous arterial blood gases and serum phosphate levels. Two patients given antacids had severe hypophosphatemia and worsened ventilatory function; phosphate-binding antacids should be used judiciously in patients with severe respiratory disease, since they may lead to the development or worsening of hypophosphatemia and diminished ventilatory function.

UR - http://www.scopus.com/inward/record.url?scp=0020680274&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020680274&partnerID=8YFLogxK

M3 - Article

C2 - 6825484

AN - SCOPUS:0020680274

VL - 83

SP - 504

EP - 508

JO - Chest

JF - Chest

SN - 0012-3692

IS - 3

ER -