Reprogramming erythroleuekmia cells to terminal differentiation and terminal cell division.

I. Matushansky, F. Radparvar, N. Rekhtman, Arthur I. Skoultchi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In vitro differentiation of murine erythroleuekemia cells recapitulates many aspects of the erythroid terminal differentiation program, including hemoglobin synthesis and proliferation arrest. It also provides an opportunity to study the changes occurring during reprogramming of tumor cells into their normal differentiation program. This review is focused on the recent progress made in understanding the key events occurring during the reprogramming of erythroleukemia cells. We discuss the contributions of PU.1 to the block to terminal differentiation exhibited by the erythroleukemia cells as well as the role of GATA-1 in restoring normal differentiation. We also discuss the role of certain cell cycle regulators in the decision to resume normal differentiation and in the resulting terminal cell divisions and arrest.

Original languageEnglish (US)
JournalFrontiers in Bioscience
Volume5
StatePublished - 2000

Fingerprint

Leukemia, Erythroblastic, Acute
Cell Division
Cells
Cell Cycle
Hemoglobins
Tumors
Neoplasms
Cellular Reprogramming
In Vitro Techniques

Cite this

Reprogramming erythroleuekmia cells to terminal differentiation and terminal cell division. / Matushansky, I.; Radparvar, F.; Rekhtman, N.; Skoultchi, Arthur I.

In: Frontiers in Bioscience, Vol. 5, 2000.

Research output: Contribution to journalArticle

@article{ce48f010246340af9c92e36b8d5bd123,
title = "Reprogramming erythroleuekmia cells to terminal differentiation and terminal cell division.",
abstract = "In vitro differentiation of murine erythroleuekemia cells recapitulates many aspects of the erythroid terminal differentiation program, including hemoglobin synthesis and proliferation arrest. It also provides an opportunity to study the changes occurring during reprogramming of tumor cells into their normal differentiation program. This review is focused on the recent progress made in understanding the key events occurring during the reprogramming of erythroleukemia cells. We discuss the contributions of PU.1 to the block to terminal differentiation exhibited by the erythroleukemia cells as well as the role of GATA-1 in restoring normal differentiation. We also discuss the role of certain cell cycle regulators in the decision to resume normal differentiation and in the resulting terminal cell divisions and arrest.",
author = "I. Matushansky and F. Radparvar and N. Rekhtman and Skoultchi, {Arthur I.}",
year = "2000",
language = "English (US)",
volume = "5",
journal = "Frontiers in Bioscience - Landmark",
issn = "1093-9946",
publisher = "Frontiers in Bioscience",

}

TY - JOUR

T1 - Reprogramming erythroleuekmia cells to terminal differentiation and terminal cell division.

AU - Matushansky, I.

AU - Radparvar, F.

AU - Rekhtman, N.

AU - Skoultchi, Arthur I.

PY - 2000

Y1 - 2000

N2 - In vitro differentiation of murine erythroleuekemia cells recapitulates many aspects of the erythroid terminal differentiation program, including hemoglobin synthesis and proliferation arrest. It also provides an opportunity to study the changes occurring during reprogramming of tumor cells into their normal differentiation program. This review is focused on the recent progress made in understanding the key events occurring during the reprogramming of erythroleukemia cells. We discuss the contributions of PU.1 to the block to terminal differentiation exhibited by the erythroleukemia cells as well as the role of GATA-1 in restoring normal differentiation. We also discuss the role of certain cell cycle regulators in the decision to resume normal differentiation and in the resulting terminal cell divisions and arrest.

AB - In vitro differentiation of murine erythroleuekemia cells recapitulates many aspects of the erythroid terminal differentiation program, including hemoglobin synthesis and proliferation arrest. It also provides an opportunity to study the changes occurring during reprogramming of tumor cells into their normal differentiation program. This review is focused on the recent progress made in understanding the key events occurring during the reprogramming of erythroleukemia cells. We discuss the contributions of PU.1 to the block to terminal differentiation exhibited by the erythroleukemia cells as well as the role of GATA-1 in restoring normal differentiation. We also discuss the role of certain cell cycle regulators in the decision to resume normal differentiation and in the resulting terminal cell divisions and arrest.

UR - http://www.scopus.com/inward/record.url?scp=2042510518&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2042510518&partnerID=8YFLogxK

M3 - Article

C2 - 10762597

AN - SCOPUS:2042510518

VL - 5

JO - Frontiers in Bioscience - Landmark

JF - Frontiers in Bioscience - Landmark

SN - 1093-9946

ER -