TY - JOUR
T1 - Reproductive and genital health and risk of cervical human papillomavirus infection
T2 - Results from the Ludwig-McGill cohort study
AU - Ludwig-McGill Cohort Study
AU - Shaw, Eileen
AU - Ramanakumar, Agnihotram V.
AU - El-Zein, Mariam
AU - Silva, Flavia R.
AU - Galan, Lenice
AU - Baggio, Maria L.
AU - Villa, Luisa L.
AU - Franco, Eduardo L.
AU - Baggio, Maria Luiza
AU - Sobrinho, João Simão
AU - Prado, José Carlos Mann
AU - Ferreira, Silvaneide
AU - Termini, Lara
AU - Costa, Maria Cecília
AU - Miyamura, Romulo
AU - Trevisan, Andrea
AU - Thomann, Patricia
AU - Candeias, João
AU - Sichero, Laura
AU - Rahal, Paula
AU - Ruiz, Antonio
AU - Kaiano, Jane
AU - Santos, Monica
AU - Savio, Patricia
AU - Maciag, Paulo
AU - Rabachini, Tatiana
AU - Rousseau, Marie Claude
AU - Mahmud, Salaheddin
AU - Schlecht, Nicolas
AU - Trottier, Helen
AU - Ferenczy, Alex
AU - Rohan, Thomas
AU - Chevarie-Davis, Myriam
AU - Louvanto, Karolina
AU - Tota, Joseph
AU - Duarte, Eliane
AU - Kulaga, Sophie
AU - Robitaille, Juliette
AU - Platt, Robert
N1 - Publisher Copyright:
© 2016 Shaw et al.
PY - 2016/3/8
Y1 - 2016/3/8
N2 - Background: There are inconsistencies in the literature on reproductive and genital health determinants of human papillomavirus (HPV) infection, the primary cause of cervical cancer. We examined these factors in the Ludwig-McGill Cohort Study, a longitudinal, repeated-measurements investigation on the natural history of HPV infection. Methods: We analyzed a cohort subset of 1867 women with one complete year of follow-up. We calculated odds ratios (OR) and 95 % confidence intervals (CI) for reproductive and genital health characteristics from questionnaire and laboratory data in relation to 1-year period prevalence of HPV infection. Two outcomes were measured; the first based on phylogenetic grouping of HPV types based on tissue tropism and oncogenicity (Alphapapillomavirus Subgenus 1: species 1, 8, 10 and 13; Subgenus 2: species 5, 6, 7, 9, 11; Subgenus 3: species 3, 4 and 14) and the second based on transient or persistent HPV infections. Results: Lifetime (Subgenus 3 OR = 2.00, CI: 1.23-3.24) and current (Subgenus 3 OR = 2.00, CI: 1.15-3.47) condom use and use of contraceptive injections (Subgenus 1 OR = 1.96, CI: 1.22-3.16, Subgenus 2 OR = 1.34, CI: 1.00-1.79) were associated with increased risk of HPV infection. Intrauterine device use was protective (Subgenus 1 OR = 0.48, CI: 0.30-0.75, Subgenus 2 OR = 0.78, CI: 0.62-0.98). These factors were not associated with persistence of HPV infection. Tampon use, previous gynecologic infections and cervical inflammation were associated with an overall increased risk of HPV infection. Conclusions: Cervical HPV infection was associated with reproductive and genital health factors. Further studies are necessary to confirm the low to moderate associations observed.
AB - Background: There are inconsistencies in the literature on reproductive and genital health determinants of human papillomavirus (HPV) infection, the primary cause of cervical cancer. We examined these factors in the Ludwig-McGill Cohort Study, a longitudinal, repeated-measurements investigation on the natural history of HPV infection. Methods: We analyzed a cohort subset of 1867 women with one complete year of follow-up. We calculated odds ratios (OR) and 95 % confidence intervals (CI) for reproductive and genital health characteristics from questionnaire and laboratory data in relation to 1-year period prevalence of HPV infection. Two outcomes were measured; the first based on phylogenetic grouping of HPV types based on tissue tropism and oncogenicity (Alphapapillomavirus Subgenus 1: species 1, 8, 10 and 13; Subgenus 2: species 5, 6, 7, 9, 11; Subgenus 3: species 3, 4 and 14) and the second based on transient or persistent HPV infections. Results: Lifetime (Subgenus 3 OR = 2.00, CI: 1.23-3.24) and current (Subgenus 3 OR = 2.00, CI: 1.15-3.47) condom use and use of contraceptive injections (Subgenus 1 OR = 1.96, CI: 1.22-3.16, Subgenus 2 OR = 1.34, CI: 1.00-1.79) were associated with increased risk of HPV infection. Intrauterine device use was protective (Subgenus 1 OR = 0.48, CI: 0.30-0.75, Subgenus 2 OR = 0.78, CI: 0.62-0.98). These factors were not associated with persistence of HPV infection. Tampon use, previous gynecologic infections and cervical inflammation were associated with an overall increased risk of HPV infection. Conclusions: Cervical HPV infection was associated with reproductive and genital health factors. Further studies are necessary to confirm the low to moderate associations observed.
KW - Cervical cancer
KW - Determinants
KW - Genital hygiene
KW - HPV
KW - Human papillomavirus
KW - Reproductive health
UR - http://www.scopus.com/inward/record.url?scp=84960090617&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960090617&partnerID=8YFLogxK
U2 - 10.1186/s12879-016-1446-x
DO - 10.1186/s12879-016-1446-x
M3 - Article
C2 - 26956880
AN - SCOPUS:84960090617
SN - 1471-2334
VL - 16
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
IS - 1
M1 - 116
ER -