Reproductive and genital health and risk of cervical human papillomavirus infection: Results from the Ludwig-McGill cohort study

Ludwig-McGill Cohort Study, Eduardo L. Franco

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: There are inconsistencies in the literature on reproductive and genital health determinants of human papillomavirus (HPV) infection, the primary cause of cervical cancer. We examined these factors in the Ludwig-McGill Cohort Study, a longitudinal, repeated-measurements investigation on the natural history of HPV infection. Methods: We analyzed a cohort subset of 1867 women with one complete year of follow-up. We calculated odds ratios (OR) and 95 % confidence intervals (CI) for reproductive and genital health characteristics from questionnaire and laboratory data in relation to 1-year period prevalence of HPV infection. Two outcomes were measured; the first based on phylogenetic grouping of HPV types based on tissue tropism and oncogenicity (Alphapapillomavirus Subgenus 1: species 1, 8, 10 and 13; Subgenus 2: species 5, 6, 7, 9, 11; Subgenus 3: species 3, 4 and 14) and the second based on transient or persistent HPV infections. Results: Lifetime (Subgenus 3 OR = 2.00, CI: 1.23-3.24) and current (Subgenus 3 OR = 2.00, CI: 1.15-3.47) condom use and use of contraceptive injections (Subgenus 1 OR = 1.96, CI: 1.22-3.16, Subgenus 2 OR = 1.34, CI: 1.00-1.79) were associated with increased risk of HPV infection. Intrauterine device use was protective (Subgenus 1 OR = 0.48, CI: 0.30-0.75, Subgenus 2 OR = 0.78, CI: 0.62-0.98). These factors were not associated with persistence of HPV infection. Tampon use, previous gynecologic infections and cervical inflammation were associated with an overall increased risk of HPV infection. Conclusions: Cervical HPV infection was associated with reproductive and genital health factors. Further studies are necessary to confirm the low to moderate associations observed.

Original languageEnglish (US)
Article number116
JournalBMC Infectious Diseases
Volume16
Issue number1
DOIs
StatePublished - Mar 8 2016
Externally publishedYes

Fingerprint

Papillomavirus Infections
Reproductive Health
Cohort Studies
Odds Ratio
Confidence Intervals
Alphapapillomavirus
Intrauterine Devices
Tropism
Condoms
Contraceptive Agents
Natural History
Uterine Cervical Neoplasms
Inflammation
Injections

Keywords

  • Cervical cancer
  • Determinants
  • Genital hygiene
  • HPV
  • Human papillomavirus
  • Reproductive health

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Reproductive and genital health and risk of cervical human papillomavirus infection : Results from the Ludwig-McGill cohort study. / Ludwig-McGill Cohort Study; Franco, Eduardo L.

In: BMC Infectious Diseases, Vol. 16, No. 1, 116, 08.03.2016.

Research output: Contribution to journalArticle

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abstract = "Background: There are inconsistencies in the literature on reproductive and genital health determinants of human papillomavirus (HPV) infection, the primary cause of cervical cancer. We examined these factors in the Ludwig-McGill Cohort Study, a longitudinal, repeated-measurements investigation on the natural history of HPV infection. Methods: We analyzed a cohort subset of 1867 women with one complete year of follow-up. We calculated odds ratios (OR) and 95 {\%} confidence intervals (CI) for reproductive and genital health characteristics from questionnaire and laboratory data in relation to 1-year period prevalence of HPV infection. Two outcomes were measured; the first based on phylogenetic grouping of HPV types based on tissue tropism and oncogenicity (Alphapapillomavirus Subgenus 1: species 1, 8, 10 and 13; Subgenus 2: species 5, 6, 7, 9, 11; Subgenus 3: species 3, 4 and 14) and the second based on transient or persistent HPV infections. Results: Lifetime (Subgenus 3 OR = 2.00, CI: 1.23-3.24) and current (Subgenus 3 OR = 2.00, CI: 1.15-3.47) condom use and use of contraceptive injections (Subgenus 1 OR = 1.96, CI: 1.22-3.16, Subgenus 2 OR = 1.34, CI: 1.00-1.79) were associated with increased risk of HPV infection. Intrauterine device use was protective (Subgenus 1 OR = 0.48, CI: 0.30-0.75, Subgenus 2 OR = 0.78, CI: 0.62-0.98). These factors were not associated with persistence of HPV infection. Tampon use, previous gynecologic infections and cervical inflammation were associated with an overall increased risk of HPV infection. Conclusions: Cervical HPV infection was associated with reproductive and genital health factors. Further studies are necessary to confirm the low to moderate associations observed.",
keywords = "Cervical cancer, Determinants, Genital hygiene, HPV, Human papillomavirus, Reproductive health",
author = "{Ludwig-McGill Cohort Study} and Eileen Shaw and Ramanakumar, {Agnihotram V.} and Mariam El-Zein and Silva, {Flavia R.} and Lenice Galan and Baggio, {Maria L.} and Franco, {Eduardo L.} and Franco, {Eduardo L.} and Baggio, {Maria Luiza} and Sobrinho, {Jo{\~a}o Sim{\~a}o} and Prado, {Jos{\'e} Carlos Mann} and Silvaneide Ferreira and Lara Termini and Costa, {Maria Cec{\'i}lia} and Romulo Miyamura and Andrea Trevisan and Patricia Thomann and Jo{\~a}o Candeias and Laura Sichero and Paula Rahal and Antonio Ruiz and Jane Kaiano and Monica Santos and Patricia Savio and Paulo Maciag and Tatiana Rabachini and Luisa Villa and Rousseau, {Marie Claude} and Salaheddin Mahmud and Nicolas Schlecht and Helen Trottier and Alex Ferenczy and Rohan, {Thomas E.} and Myriam Chevarie-Davis and Karolina Louvanto and Joseph Tota and Agnihotram Ramanakumar and Eliane Duarte and Flavia Silva and Sophie Kulaga and Juliette Robitaille and Robert Platt and Eduardo Franco",
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T2 - Results from the Ludwig-McGill cohort study

AU - Ludwig-McGill Cohort Study

AU - Shaw, Eileen

AU - Ramanakumar, Agnihotram V.

AU - El-Zein, Mariam

AU - Silva, Flavia R.

AU - Galan, Lenice

AU - Baggio, Maria L.

AU - Franco, Eduardo L.

AU - Franco, Eduardo L.

AU - Baggio, Maria Luiza

AU - Sobrinho, João Simão

AU - Prado, José Carlos Mann

AU - Ferreira, Silvaneide

AU - Termini, Lara

AU - Costa, Maria Cecília

AU - Miyamura, Romulo

AU - Trevisan, Andrea

AU - Thomann, Patricia

AU - Candeias, João

AU - Sichero, Laura

AU - Rahal, Paula

AU - Ruiz, Antonio

AU - Kaiano, Jane

AU - Santos, Monica

AU - Savio, Patricia

AU - Maciag, Paulo

AU - Rabachini, Tatiana

AU - Villa, Luisa

AU - Rousseau, Marie Claude

AU - Mahmud, Salaheddin

AU - Schlecht, Nicolas

AU - Trottier, Helen

AU - Ferenczy, Alex

AU - Rohan, Thomas E.

AU - Chevarie-Davis, Myriam

AU - Louvanto, Karolina

AU - Tota, Joseph

AU - Ramanakumar, Agnihotram

AU - Duarte, Eliane

AU - Silva, Flavia

AU - Kulaga, Sophie

AU - Robitaille, Juliette

AU - Platt, Robert

AU - Franco, Eduardo

PY - 2016/3/8

Y1 - 2016/3/8

N2 - Background: There are inconsistencies in the literature on reproductive and genital health determinants of human papillomavirus (HPV) infection, the primary cause of cervical cancer. We examined these factors in the Ludwig-McGill Cohort Study, a longitudinal, repeated-measurements investigation on the natural history of HPV infection. Methods: We analyzed a cohort subset of 1867 women with one complete year of follow-up. We calculated odds ratios (OR) and 95 % confidence intervals (CI) for reproductive and genital health characteristics from questionnaire and laboratory data in relation to 1-year period prevalence of HPV infection. Two outcomes were measured; the first based on phylogenetic grouping of HPV types based on tissue tropism and oncogenicity (Alphapapillomavirus Subgenus 1: species 1, 8, 10 and 13; Subgenus 2: species 5, 6, 7, 9, 11; Subgenus 3: species 3, 4 and 14) and the second based on transient or persistent HPV infections. Results: Lifetime (Subgenus 3 OR = 2.00, CI: 1.23-3.24) and current (Subgenus 3 OR = 2.00, CI: 1.15-3.47) condom use and use of contraceptive injections (Subgenus 1 OR = 1.96, CI: 1.22-3.16, Subgenus 2 OR = 1.34, CI: 1.00-1.79) were associated with increased risk of HPV infection. Intrauterine device use was protective (Subgenus 1 OR = 0.48, CI: 0.30-0.75, Subgenus 2 OR = 0.78, CI: 0.62-0.98). These factors were not associated with persistence of HPV infection. Tampon use, previous gynecologic infections and cervical inflammation were associated with an overall increased risk of HPV infection. Conclusions: Cervical HPV infection was associated with reproductive and genital health factors. Further studies are necessary to confirm the low to moderate associations observed.

AB - Background: There are inconsistencies in the literature on reproductive and genital health determinants of human papillomavirus (HPV) infection, the primary cause of cervical cancer. We examined these factors in the Ludwig-McGill Cohort Study, a longitudinal, repeated-measurements investigation on the natural history of HPV infection. Methods: We analyzed a cohort subset of 1867 women with one complete year of follow-up. We calculated odds ratios (OR) and 95 % confidence intervals (CI) for reproductive and genital health characteristics from questionnaire and laboratory data in relation to 1-year period prevalence of HPV infection. Two outcomes were measured; the first based on phylogenetic grouping of HPV types based on tissue tropism and oncogenicity (Alphapapillomavirus Subgenus 1: species 1, 8, 10 and 13; Subgenus 2: species 5, 6, 7, 9, 11; Subgenus 3: species 3, 4 and 14) and the second based on transient or persistent HPV infections. Results: Lifetime (Subgenus 3 OR = 2.00, CI: 1.23-3.24) and current (Subgenus 3 OR = 2.00, CI: 1.15-3.47) condom use and use of contraceptive injections (Subgenus 1 OR = 1.96, CI: 1.22-3.16, Subgenus 2 OR = 1.34, CI: 1.00-1.79) were associated with increased risk of HPV infection. Intrauterine device use was protective (Subgenus 1 OR = 0.48, CI: 0.30-0.75, Subgenus 2 OR = 0.78, CI: 0.62-0.98). These factors were not associated with persistence of HPV infection. Tampon use, previous gynecologic infections and cervical inflammation were associated with an overall increased risk of HPV infection. Conclusions: Cervical HPV infection was associated with reproductive and genital health factors. Further studies are necessary to confirm the low to moderate associations observed.

KW - Cervical cancer

KW - Determinants

KW - Genital hygiene

KW - HPV

KW - Human papillomavirus

KW - Reproductive health

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