Replete vitamin D stores predict reproductive success following in vitro fertilization

Sebiha Ozkan, Sangita Jindal, Keri Greenseid, Jun Shu, Gohar Zeitlian, Cheryl Hickmon, Lubna Pal

Research output: Contribution to journalArticle

182 Scopus citations

Abstract

Objective: To determine whether 25OH-D levels in the follicular fluid (FF) of infertile women undergoing IVF demonstrate a relationship with IVF cycle parameters and outcome, hypothesizing that levels of 25OH-D in body fluids are reflective of vitamin repletion status. Design: Prospective cohort study. Setting: Academic tertiary care center. Patient(s): Eighty-four infertile women undergoing IVF. Intervention(s): Follicular fluid from follicles ≥14mm; serum (n = 10) and FF levels of 25OH-D. Main Outcome Measure(s): Clinical pregnancy (CP), defined as evidence of intrauterine gestation sac on ultrasound, following IVF; IVF cycle parameters. Result(s): Serum and FF levels of 25OH-D were highly correlated (r = 0.94). In a predominantly Caucasian population (66%), significantly lower FF 25OH-D levels were noted in Black versus non-Black patients. Significant inverse correlations were seen between FF 25OH-D levels and body mass index (r = -0.25). Significantly higher CP and implantation rates were observed across tertiles of FF25OH-D; patients achieving CP following IVF (n = 26) exhibited significantly higher FF levels of 25OH-D. Multivariable logistic regression analysis confirmed FF 25OH-D levels as an independent predictor to success of an IVF cycle; adjusting for age, body mass index, ethnicity, and number of embryos transferred, each ng/mL increase in FF 25OH-D increased the likelihood for achieving CP by 6%. Conclusion(s): Our findings that women with higher vitamin D level in their serum and FF are significantly more likely to achieve CP following IVF-embryo transfer are novel. A potential for benefit of vitamin D supplementation on treatment success in infertile patients undergoing IVF is suggested and merits further investigation.

Original languageEnglish (US)
Pages (from-to)1314-1319
Number of pages6
JournalFertility and sterility
Volume94
Issue number4
DOIs
StatePublished - Sep 1 2010

Keywords

  • 25OH-D
  • Vitamin D
  • clinical pregnancy
  • follicular fluid
  • in vitro fertilization
  • infertility

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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