REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers

the AJ LRRK2 Consortium

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Rapid eye movement sleep behavior disorder occurs with idiopathic Parkinson's disease (PD) and often precedes PD. Its frequency in LRRK2-PD and utility as a preclinical marker has not been established. Methods: One hundred forty-four idiopathic PD, 142 LRRK2 G2019S mutation PD, 117 non-manifesting carriers, 93 related noncarriers, and 40 healthy controls completed the Rapid eye movement sleep Behavior Disorder Screening Questionnaire. Results: Cut scores were met by 30.6% idiopathic PD, 19.7% LRRK2-PD, 6% nonmanifesting carriers, 20.4% related noncarriers, and 15% controls. The likelihood of abnormal scores was decreased in LRRK2-PD versus idiopathic PD (odds ratio = 0.55, P = 0.03), nonmanifesting carriers versus related noncarriers (OR = 0.25, P <0.01), and PD of less than 3 years' duration, 1 of 19 LRRK2-PD versus 14 of 41 idiopathic PD (P <0.05). Conclusions: A lower frequency of abnormal questionnaire scores is seen in LRRK2-PD, especially in early LRRK2-PD, and in nonmanifesting carriers. Therefore, the Rapid eye movement sleep Behavior Disorder Questionnaire is unlikely to serve as a preclinical marker for phenoconversion to PD.

Original languageEnglish (US)
Pages (from-to)1834-1839
Number of pages6
JournalMovement Disorders
Volume30
Issue number13
DOIs
StatePublished - Nov 1 2015

Fingerprint

REM Sleep Behavior Disorder
Parkinson Disease
Mutation
Surveys and Questionnaires

Keywords

  • LRRK2
  • Parkinson's disease
  • preclinical
  • RBDSQ
  • REM Behavior Disorder

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers. / the AJ LRRK2 Consortium.

In: Movement Disorders, Vol. 30, No. 13, 01.11.2015, p. 1834-1839.

Research output: Contribution to journalArticle

@article{91b0894198da4adb94bad675e6f65120,
title = "REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers",
abstract = "Background: Rapid eye movement sleep behavior disorder occurs with idiopathic Parkinson's disease (PD) and often precedes PD. Its frequency in LRRK2-PD and utility as a preclinical marker has not been established. Methods: One hundred forty-four idiopathic PD, 142 LRRK2 G2019S mutation PD, 117 non-manifesting carriers, 93 related noncarriers, and 40 healthy controls completed the Rapid eye movement sleep Behavior Disorder Screening Questionnaire. Results: Cut scores were met by 30.6{\%} idiopathic PD, 19.7{\%} LRRK2-PD, 6{\%} nonmanifesting carriers, 20.4{\%} related noncarriers, and 15{\%} controls. The likelihood of abnormal scores was decreased in LRRK2-PD versus idiopathic PD (odds ratio = 0.55, P = 0.03), nonmanifesting carriers versus related noncarriers (OR = 0.25, P <0.01), and PD of less than 3 years' duration, 1 of 19 LRRK2-PD versus 14 of 41 idiopathic PD (P <0.05). Conclusions: A lower frequency of abnormal questionnaire scores is seen in LRRK2-PD, especially in early LRRK2-PD, and in nonmanifesting carriers. Therefore, the Rapid eye movement sleep Behavior Disorder Questionnaire is unlikely to serve as a preclinical marker for phenoconversion to PD.",
keywords = "LRRK2, Parkinson's disease, preclinical, RBDSQ, REM Behavior Disorder",
author = "{the AJ LRRK2 Consortium} and Rachel Saunders-Pullman and Alcalay, {Roy N.} and Anat Mirelman and Cuiling Wang and Luciano, {Marta San} and Ortega, {Roberto A.} and Amanda Glickman and Deborah Raymond and Helen Mejia-Santana and Nancy Doan and Brooke Johannes and Kira Yasinovsky and Laurie Ozelius and Lorraine Clark and Avi Orr-Utreger and Karen Marder and Nir Giladi and Bressman, {Susan B.}",
year = "2015",
month = "11",
day = "1",
doi = "10.1002/mds.26413",
language = "English (US)",
volume = "30",
pages = "1834--1839",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "13",

}

TY - JOUR

T1 - REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers

AU - the AJ LRRK2 Consortium

AU - Saunders-Pullman, Rachel

AU - Alcalay, Roy N.

AU - Mirelman, Anat

AU - Wang, Cuiling

AU - Luciano, Marta San

AU - Ortega, Roberto A.

AU - Glickman, Amanda

AU - Raymond, Deborah

AU - Mejia-Santana, Helen

AU - Doan, Nancy

AU - Johannes, Brooke

AU - Yasinovsky, Kira

AU - Ozelius, Laurie

AU - Clark, Lorraine

AU - Orr-Utreger, Avi

AU - Marder, Karen

AU - Giladi, Nir

AU - Bressman, Susan B.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Background: Rapid eye movement sleep behavior disorder occurs with idiopathic Parkinson's disease (PD) and often precedes PD. Its frequency in LRRK2-PD and utility as a preclinical marker has not been established. Methods: One hundred forty-four idiopathic PD, 142 LRRK2 G2019S mutation PD, 117 non-manifesting carriers, 93 related noncarriers, and 40 healthy controls completed the Rapid eye movement sleep Behavior Disorder Screening Questionnaire. Results: Cut scores were met by 30.6% idiopathic PD, 19.7% LRRK2-PD, 6% nonmanifesting carriers, 20.4% related noncarriers, and 15% controls. The likelihood of abnormal scores was decreased in LRRK2-PD versus idiopathic PD (odds ratio = 0.55, P = 0.03), nonmanifesting carriers versus related noncarriers (OR = 0.25, P <0.01), and PD of less than 3 years' duration, 1 of 19 LRRK2-PD versus 14 of 41 idiopathic PD (P <0.05). Conclusions: A lower frequency of abnormal questionnaire scores is seen in LRRK2-PD, especially in early LRRK2-PD, and in nonmanifesting carriers. Therefore, the Rapid eye movement sleep Behavior Disorder Questionnaire is unlikely to serve as a preclinical marker for phenoconversion to PD.

AB - Background: Rapid eye movement sleep behavior disorder occurs with idiopathic Parkinson's disease (PD) and often precedes PD. Its frequency in LRRK2-PD and utility as a preclinical marker has not been established. Methods: One hundred forty-four idiopathic PD, 142 LRRK2 G2019S mutation PD, 117 non-manifesting carriers, 93 related noncarriers, and 40 healthy controls completed the Rapid eye movement sleep Behavior Disorder Screening Questionnaire. Results: Cut scores were met by 30.6% idiopathic PD, 19.7% LRRK2-PD, 6% nonmanifesting carriers, 20.4% related noncarriers, and 15% controls. The likelihood of abnormal scores was decreased in LRRK2-PD versus idiopathic PD (odds ratio = 0.55, P = 0.03), nonmanifesting carriers versus related noncarriers (OR = 0.25, P <0.01), and PD of less than 3 years' duration, 1 of 19 LRRK2-PD versus 14 of 41 idiopathic PD (P <0.05). Conclusions: A lower frequency of abnormal questionnaire scores is seen in LRRK2-PD, especially in early LRRK2-PD, and in nonmanifesting carriers. Therefore, the Rapid eye movement sleep Behavior Disorder Questionnaire is unlikely to serve as a preclinical marker for phenoconversion to PD.

KW - LRRK2

KW - Parkinson's disease

KW - preclinical

KW - RBDSQ

KW - REM Behavior Disorder

UR - http://www.scopus.com/inward/record.url?scp=84978505267&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978505267&partnerID=8YFLogxK

U2 - 10.1002/mds.26413

DO - 10.1002/mds.26413

M3 - Article

C2 - 26366513

AN - SCOPUS:84978505267

VL - 30

SP - 1834

EP - 1839

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 13

ER -