REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers

the AJ LRRK2 Consortium

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background: Rapid eye movement sleep behavior disorder occurs with idiopathic Parkinson's disease (PD) and often precedes PD. Its frequency in LRRK2-PD and utility as a preclinical marker has not been established. Methods: One hundred forty-four idiopathic PD, 142 LRRK2 G2019S mutation PD, 117 non-manifesting carriers, 93 related noncarriers, and 40 healthy controls completed the Rapid eye movement sleep Behavior Disorder Screening Questionnaire. Results: Cut scores were met by 30.6% idiopathic PD, 19.7% LRRK2-PD, 6% nonmanifesting carriers, 20.4% related noncarriers, and 15% controls. The likelihood of abnormal scores was decreased in LRRK2-PD versus idiopathic PD (odds ratio = 0.55, P = 0.03), nonmanifesting carriers versus related noncarriers (OR = 0.25, P < 0.01), and PD of less than 3 years' duration, 1 of 19 LRRK2-PD versus 14 of 41 idiopathic PD (P < 0.05). Conclusions: A lower frequency of abnormal questionnaire scores is seen in LRRK2-PD, especially in early LRRK2-PD, and in nonmanifesting carriers. Therefore, the Rapid eye movement sleep Behavior Disorder Questionnaire is unlikely to serve as a preclinical marker for phenoconversion to PD.

Original languageEnglish (US)
Pages (from-to)1834-1839
Number of pages6
JournalMovement Disorders
Volume30
Issue number13
DOIs
StatePublished - Nov 1 2015

Keywords

  • LRRK2
  • Parkinson's disease
  • RBDSQ
  • REM Behavior Disorder
  • preclinical

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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