Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots

Daniella E. Chusyd, Donghai Wang, Derek M. Huffman, Tim R. Nagy

Research output: Contribution to journalReview article

90 Scopus citations

Abstract

The objective of this review was to compare and contrast the physiological and metabolic profiles of rodent white adipose fat pads with white adipose fat depots in humans. Human fat distribution and its metabolic consequences have received extensive attention, but much of what has been tested in translational research has relied heavily on rodents. Unfortunately, the validity of using rodent fat pads as a model of human adiposity has received less attention. There is a surprisingly lack of studies demonstrating an analogous relationship between rodent and human adiposity on obesity-related comorbidities. Therefore, we aimed to compare known similarities and disparities in terms of white adipose tissue (WAT) development and distribution, sexual dimorphism, weight loss, adipokine secretion, and aging. While the literature supports the notion that many similarities exist between rodents and humans, notable differences emerge related to fat deposition and function of WAT. Thus, further research is warranted to more carefully define the strengths and limitations of rodent WAT as a model for humans, with a particular emphasis on comparable fat depots, such as mesenteric fat.

Original languageEnglish (US)
Article number10
JournalFrontiers in Nutrition
Volume3
DOIs
StatePublished - Apr 19 2016

Keywords

  • fat depot
  • fat distribution
  • fat pads
  • humans
  • obesity
  • rodents

ASJC Scopus subject areas

  • Food Science
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots'. Together they form a unique fingerprint.

  • Cite this