Relationship between platelet count and hemodialysis membranes

Rabih Nasr, Chadi Saifan, Iskandar Barakat, Yorg Al Azzi, Ali Naboush, Marc Saad, Suzanne El Sayegh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: One factor associated with poor outcomes in hemodialysis patients is exposure to a foreign membrane. Older membranes are very bioincompatible and increase complement activation, cause leukocytosis by activating circulating factors, which sequesters leukocytes in the lungs, and activates platelets. Recently, newer membranes have been developed that were designed to be more biocompatible. We tested if the different "optiflux" hemodialysis membranes had different effects on platelet levels. Methods: Ninety-nine maintenance hemodialysis patients with no known systemic or hematologic diseases affecting their platelets had blood drawn immediately prior to, 90 minutes into, and immediately following their first hemodialysis session of the week. All patients were dialyzed using a Fresenius Medical Care Optiflux polysulfone membrane F160, F180, or F200 (polysulfone synthetic dialyzer membranes, 1.6 m2, 1.8 m2, and 2.0 m2 surface area, respectively, electron beam sterilized). Platelet counts were measured from each sample by analysis using a CBC analyzer. Results: The average age of the patients was 62.7 years; 36 were female and 63 were male. The mean platelet count pre, mid, and post dialysis was 193 (standard deviation ±74.86), 191 (standard deviation ±74.67), and 197 (standard deviation ±79.34) thousand/mm3, respectively, with no statistical differences. Conclusion: Newer membranes have no significant effect on platelet count. This suggests that they are, in fact, more biocompatible than their predecessors and may explain their association with increased survival.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalInternational Journal of Nephrology and Renovascular Disease
Volume6
DOIs
StatePublished - Aug 19 2013
Externally publishedYes

Fingerprint

Platelet Count
Renal Dialysis
Membranes
Blood Platelets
Hematologic Diseases
Complement Activation
Leukocytosis
Dialysis
Leukocytes
Maintenance
Electrons
Lung
Survival

Keywords

  • Bioincompatible events
  • Cellulosic membranes
  • Complement activation
  • Electron beam sterilized
  • Platelet count
  • Polysulfone membranes

ASJC Scopus subject areas

  • Nephrology

Cite this

Relationship between platelet count and hemodialysis membranes. / Nasr, Rabih; Saifan, Chadi; Barakat, Iskandar; Azzi, Yorg Al; Naboush, Ali; Saad, Marc; Sayegh, Suzanne El.

In: International Journal of Nephrology and Renovascular Disease, Vol. 6, 19.08.2013, p. 143-147.

Research output: Contribution to journalArticle

Nasr, Rabih ; Saifan, Chadi ; Barakat, Iskandar ; Azzi, Yorg Al ; Naboush, Ali ; Saad, Marc ; Sayegh, Suzanne El. / Relationship between platelet count and hemodialysis membranes. In: International Journal of Nephrology and Renovascular Disease. 2013 ; Vol. 6. pp. 143-147.
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N2 - Background: One factor associated with poor outcomes in hemodialysis patients is exposure to a foreign membrane. Older membranes are very bioincompatible and increase complement activation, cause leukocytosis by activating circulating factors, which sequesters leukocytes in the lungs, and activates platelets. Recently, newer membranes have been developed that were designed to be more biocompatible. We tested if the different "optiflux" hemodialysis membranes had different effects on platelet levels. Methods: Ninety-nine maintenance hemodialysis patients with no known systemic or hematologic diseases affecting their platelets had blood drawn immediately prior to, 90 minutes into, and immediately following their first hemodialysis session of the week. All patients were dialyzed using a Fresenius Medical Care Optiflux polysulfone membrane F160, F180, or F200 (polysulfone synthetic dialyzer membranes, 1.6 m2, 1.8 m2, and 2.0 m2 surface area, respectively, electron beam sterilized). Platelet counts were measured from each sample by analysis using a CBC analyzer. Results: The average age of the patients was 62.7 years; 36 were female and 63 were male. The mean platelet count pre, mid, and post dialysis was 193 (standard deviation ±74.86), 191 (standard deviation ±74.67), and 197 (standard deviation ±79.34) thousand/mm3, respectively, with no statistical differences. Conclusion: Newer membranes have no significant effect on platelet count. This suggests that they are, in fact, more biocompatible than their predecessors and may explain their association with increased survival.

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