Relationship between dental factors and risk of upper aerodigestive tract cancer

A. M. Velly, E. L. Franco, N. Schlecht, J. Pintos, L. P. Kowalski, B. V. Oliveira, M. P. Curado

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

We examined the relationship between dental health variables and risk of upper aerodigestive tract (UADT) cancers in a casecontrol study in Southern Brazil. The study population included 717 cases of cancers of the mouth, pharynx, and larynx and 1434 controls matched on age, gender, period of admission and study site. The association with dental factors was investigated by conditional logistic regression using extensive adjustment for a priori and empirical confounders, including tobacco and alcohol consumption, diet and sociodemographic variables. Lifetime use of dentures was not associated with risk of any UADT cancer, but history of oral sores secondary to ill-fitting dentures was associated with cancers of the mouth (odds ratio [OR] = 2.3, 95% confidence interval [CI] 1.2-4.6) and of the pharynx (OR = 2.7, 95% CI 1.1-6.2) among those using dentures. The association for mouth cancers was restricted primarily to an increased risk of tongue neoplasms (OR = 9.1, 95% CI 1.9-43.4). Less than daily tooth brushing frequency was also associated with risk of cancer of the tongue (OR = 2.1, 95% CI 1.0-4.3) and of other parts of the mouth (OR = 2.4, 95% CI 1.0- 5.4). Having broken teeth was not significantly associated with risk of UADT cancer of any site. We conclude that poor oral hygiene due to infrequent tooth brushing and sores caused by dentures are risk factors for cancer of the mouth and that these associations are unlikely to be due to insufficient control of confounding.

Original languageEnglish (US)
Pages (from-to)284-291
Number of pages8
JournalOral Oncology
Volume34
Issue number4
DOIs
StatePublished - Jul 1998
Externally publishedYes

Fingerprint

Mouth Neoplasms
Dentures
Tooth
Odds Ratio
Confidence Intervals
Tongue Neoplasms
Neoplasms
Pharyngeal Neoplasms
Laryngeal Neoplasms
Oral Hygiene
Tobacco Use
Pharynx
Alcohol Drinking
Brazil
Mouth
Logistic Models
Diet
Health
Population

Keywords

  • Case-control study
  • Dentition
  • Epidemiological methods
  • Oral cancer
  • Oral hygiene

ASJC Scopus subject areas

  • Oncology

Cite this

Velly, A. M., Franco, E. L., Schlecht, N., Pintos, J., Kowalski, L. P., Oliveira, B. V., & Curado, M. P. (1998). Relationship between dental factors and risk of upper aerodigestive tract cancer. Oral Oncology, 34(4), 284-291. https://doi.org/10.1016/S1368-8375(98)00003-7

Relationship between dental factors and risk of upper aerodigestive tract cancer. / Velly, A. M.; Franco, E. L.; Schlecht, N.; Pintos, J.; Kowalski, L. P.; Oliveira, B. V.; Curado, M. P.

In: Oral Oncology, Vol. 34, No. 4, 07.1998, p. 284-291.

Research output: Contribution to journalArticle

Velly, AM, Franco, EL, Schlecht, N, Pintos, J, Kowalski, LP, Oliveira, BV & Curado, MP 1998, 'Relationship between dental factors and risk of upper aerodigestive tract cancer', Oral Oncology, vol. 34, no. 4, pp. 284-291. https://doi.org/10.1016/S1368-8375(98)00003-7
Velly AM, Franco EL, Schlecht N, Pintos J, Kowalski LP, Oliveira BV et al. Relationship between dental factors and risk of upper aerodigestive tract cancer. Oral Oncology. 1998 Jul;34(4):284-291. https://doi.org/10.1016/S1368-8375(98)00003-7
Velly, A. M. ; Franco, E. L. ; Schlecht, N. ; Pintos, J. ; Kowalski, L. P. ; Oliveira, B. V. ; Curado, M. P. / Relationship between dental factors and risk of upper aerodigestive tract cancer. In: Oral Oncology. 1998 ; Vol. 34, No. 4. pp. 284-291.
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