Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal women

Anne McTiernan, LieLing Wu, Vanessa M. Barnabei, Chu Chen, Susan Hendrix, Francesmary Modugno, Thomas E. Rohan, Frank Z. Stanczyk, C. Y. Wang

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In postmenopausal women, levels of estrogens, androgens, and perhaps prolactin have been related to risk of breast and other hormonal cancers in women. However, the determinants of these hormone concentrations have not been firmly established. Associations among various demographic, menstrual, and reproductive factors, medication use and endogenous sex hormone concentrations (estradiol, free estradiol, estrone, estrone sulfate, testosterone, free testosterone, sex hormone binding globulin, androstenedione, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), dihydrotestosterone, and prolactin) were evaluated in a cross-sectional analysis from a simple random sample of 274 postmenopausal women selected from the Women's Health Initiative Dietary Modification Trial. In multiple regression analyses on log-transformed hormones, the concentrations of DHEA, and DHEAS were negatively and statistically significantly associated with age (both β = -0.03, P < 0.001, respectively). Estradiol, estrone, DHEA, and free testosterone concentrations were higher in African-American than in non-Hispanic White women, but after multivariate adjustment the associations were statistically significant only for free testosterone (β = 0.38, P = 0.01). Women who had a history of bilateral oophorectomy had a mean 35% lower testosterone concentration compared with women with at least one ovary remaining (β = -0.43, P = 0.002), and lower free testosterone (β = -0.42, P = 0.04) after multivariate adjustment. Women who reported regular use of NSAIDs had higher DHEA concentrations (β = 0.20, P = 0.04) and lower prolactin concentrations (β = -0.18, P = 0.02) compared with non-users. These results suggest that while age, oophorectomy status, and NSAID use may be associated with selected sex hormone concentrations, few menstrual or reproductive factors affect endogenous sex hormones in the postmenopausal period.

Original languageEnglish (US)
Pages (from-to)217-231
Number of pages15
JournalBreast Cancer Research and Treatment
Volume108
Issue number2
DOIs
StatePublished - Mar 2008

Fingerprint

Gonadal Steroid Hormones
Reproduction
Testosterone
Demography
Dehydroepiandrosterone Sulfate
Dehydroepiandrosterone
Prolactin
Estradiol
Estrone
Ovariectomy
Non-Steroidal Anti-Inflammatory Agents
Hormones
Postmenopause
Diet Therapy
Sex Hormone-Binding Globulin
Androstenedione
Dihydrotestosterone
Women's Health
African Americans
Androgens

Keywords

  • Breast cancer
  • Estradiol
  • Estrone
  • Hormones
  • Menopause
  • Postmenopausal
  • Prolactin
  • Sex hormone binding globulin
  • Sex hormones
  • Testosterone

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal women. / McTiernan, Anne; Wu, LieLing; Barnabei, Vanessa M.; Chen, Chu; Hendrix, Susan; Modugno, Francesmary; Rohan, Thomas E.; Stanczyk, Frank Z.; Wang, C. Y.

In: Breast Cancer Research and Treatment, Vol. 108, No. 2, 03.2008, p. 217-231.

Research output: Contribution to journalArticle

McTiernan, Anne ; Wu, LieLing ; Barnabei, Vanessa M. ; Chen, Chu ; Hendrix, Susan ; Modugno, Francesmary ; Rohan, Thomas E. ; Stanczyk, Frank Z. ; Wang, C. Y. / Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal women. In: Breast Cancer Research and Treatment. 2008 ; Vol. 108, No. 2. pp. 217-231.
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