Relapsing autoimmune demyelination: a role for vascular addressins

Barbara Cannella, Anne H. Cross, Cedric S. Raine

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The expression of two vascular addressins, adhesion molecules implicated in lymphocyte traffic via high endothelial venules (HEV) within lymph node and mucosal tissues, and of an HEV differentiation antigen (Ag) has been followed immunocytochemically in the central nervous system (CNS) of SJL mice at different stages of adoptively-transferred, chronic relapsing experimental autoimmune encephalomyelitis (EAE). Monoclonal antibody (mAb), MECA-325, which defines an HEV cell differentiation Ag generally associated with vessels involved in lymphocyte traffic, gave consistently high levels of expression on and around blood vessels within spinal cord lesions during periods of inflammation (acute onset and relapses). Two mAbs, MECA-89 and MECA-367, both recognizing the same mucosal adressin showed an affinity for endothelial cells and some astrocytes but only in lesions from animals displaying relapses. MECA-79, an mAb against a peripheral lymph node vascular addressin, showed no CNS staining whatsoever. All four antibodies gave uniformly positive staining on control lymphoid tissue. Since some stages of EAE appeared to be associated with the expression of different addressins, the possibility of separate roles for these distinct molecules should be considered.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalJournal of Neuroimmunology
Volume35
Issue number1-3
DOIs
StatePublished - Dec 1991

Keywords

  • Addressins
  • Central nervous system
  • Demyelination
  • Experimental autoimmune encephalomyelitis
  • Inflammation
  • Lymphocyte traffic
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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