Reirradiation of recurrent meningioma

Andrzej P. Wojcieszynski, Nitin Ohri, David W. Andrews, James J. Evans, Adam P. Dicker, Maria Werner-Wasik

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Management of meningioma includes observation, resection, and radiation therapy (RT). For patients with recurrent disease, similar options exist. However, the control rate following a second course of RT for recurrent disease is unknown. We reviewed an institutional database of patients with meningioma treated with stereotactic radiosurgery or fractionated stereotactic RT who underwent a second course for recurrent disease. Cox regression model was used for analysis. Variables tested included tumor volume, RT type, tumor grade, age at diagnosis, time to progression, and interval between RT. Eleven of 19 patients (58%) experienced disease progression. Median time to second progression was 10 months. Freedom from progression at one year was lower in patients with grade II or III tumors compared to those with grade 1 or unknown histology (17% compared to 92%, p = 0.0054). Cox regression showed that a grade II-III tumor affects progression-free survival (PFS), with a hazard ratio of 5.37 (p = 0.011). Median time to progression (MTP) for patients with grade II-III tumors was eight months. MTP was not reached for patients with grade 1/unknown tumors. Reirradiation for recurrent meningioma yields modest tumor control rates but for patients with grade II or III tumors, outcomes are poor.

Original languageEnglish (US)
Pages (from-to)1261-1264
Number of pages4
JournalJournal of Clinical Neuroscience
Volume19
Issue number9
DOIs
StatePublished - Sep 1 2012

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Keywords

  • Meningioma
  • Radiation therapy
  • Radiosurgery
  • Recurrent
  • Tumor

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Wojcieszynski, A. P., Ohri, N., Andrews, D. W., Evans, J. J., Dicker, A. P., & Werner-Wasik, M. (2012). Reirradiation of recurrent meningioma. Journal of Clinical Neuroscience, 19(9), 1261-1264. https://doi.org/10.1016/j.jocn.2012.01.023