Reinventing the wheel of cyclic AMP novel mechanisms of cAMP signaling

Khew Voon Chin, Weng Lang Yang, Roald Ravatn, Tsunekazu Kita, Elena Reitman, David Vettori, Mary Ellen Cvijic, Michael Shin, Lisa Iacono

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

Mechanisms of cAMP signal transduction have been thoroughly investigated for more than 40 years. From the binding of hormonal ligands to their receptors on the outer surface of the plasma membrane to the cytoplasmic activation of effectors, the ensuing cAMP signaling cascades and the nuclear gene regulatory functions, coupled with the structural elucidation of the cAMP-dependent protein kinase (PKA) and in vivo functional characterizations of each of the components of PKA by homologous recombination gene targeting, our understanding of cAMP-mediated signal transduction has reached its pinnacle. Despite this trove of knowledge, some recent findings have emerged that suggest hitherto novel and alternative mechanisms of cAMP action that could increase the signaling bandwidth of cAMP and PKA in cell growth and transcriptional regulation. This article attempts to review some of these novel and unconventional mechanisms of cAMP and PKA signaling, and to generate further enthusiasm in investigating and validating these new frontiers of the cAMP signal transduction pathway.

Original languageEnglish (US)
Pages (from-to)49-64
Number of pages16
JournalAnnals of the New York Academy of Sciences
Volume968
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • CAMP-dependent protein kinase (PKA)
  • Cyclic AMP (cAMP)
  • Function
  • Mechanism
  • Regulation
  • Regulatory subunit
  • Signal transduction

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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