Regulatory Roles of Metabotropic Glutamate Receptors on Synaptic Communication Mediated by Gap Junctions

Roger Cachope, Alberto E. Pereda

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Variations of synaptic strength are thought to underlie forms of learning and can functionally reshape neural circuits. Metabotropic glutamate receptors play key roles in regulating the strength of chemical synapses. However, information within neural circuits is also conveyed via a second modality of transmission: gap junction-mediated synapses. We review here evidence indicating that metabotropic glutamate receptors also play important roles in the regulation of synaptic communication mediated by neuronal gap junctions, also known as ‘electrical synapses’. Activity-driven interactions between metabotropic glutamate receptors and neuronal gap junctions can lead to long-term changes in the strength of electrical synapses. Further, the regulatory action of metabotropic glutamate receptors on neuronal gap junctions is not restricted to adulthood but is also of critical relevance during brain development and contributes to the pathological mechanisms that follow brain injury.

Original languageEnglish (US)
Pages (from-to)85-94
Number of pages10
JournalNeuroscience
Volume456
DOIs
StatePublished - Feb 21 2021

Keywords

  • connexin
  • electrical coupling
  • neuronal injury
  • synaptic development
  • synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

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