Regulation of T-cell tolerance by calcium/NFAT signaling

Ian Baine, Brian T. Abe, Fernando Macian

Research output: Contribution to journalReview article

62 Scopus citations

Abstract

Cells that escape negative selection in the thymus must be inactivated or eliminated in the periphery through a series of mechanisms that include the induction of anergy, dominant suppression by regulatory T cells, and peripheral deletion of self-reactive T cells. Calcium signaling plays a central role in the induction of anergy in T cells, which become functionally inactivated and incapable of proliferating and expressing cytokines following antigen re-encounter. Suboptimal stimulation of T cells results in the activation of a calcium/calcineurin/nuclear factor of activated T cells-dependent cell-intrinsic program of self-inactivation. The proteins encoded by those genes are required to impose a state of functional unresponsiveness through different mechanisms that include downregulation of T-cell receptor signaling and inhibition of cytokine transcription.

Original languageEnglish (US)
Pages (from-to)225-240
Number of pages16
JournalImmunological Reviews
Volume231
Issue number1
DOIs
Publication statusPublished - Sep 1 2009

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Keywords

  • Anergy
  • NFAT
  • Signal transduction
  • T cells
  • Transcription factors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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