Regulation of Hh signal transduction as Drosophila eye differentiation progresses

Nicholas E. Baker, Abhishek Bhattacharya, Lucy C. Firth

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Differentiation of the Drosophila retina occurs as a morphogenetic furrow sweeps anteriorly across the eye imaginal disc, driven by Hedgehog secretion from photoreceptor precursors differentiating behind the furrow. A BTB protein, Roadkill, is expressed posterior to the furrow and targets the Hedgehog signal transduction component Cubitus interruptus for degradation by Cullin-3 and the proteosome. Clonal analysis and conditional mutant studies establish that roadkill transcription is activated by the EGF receptor and Ras pathway in most differentiating retinal cells, and by both EGF receptor/Ras and by Hedgehog signaling in cells that remain unspecified. These findings outline a circuit by which Hedgehog signal transduction is modified as Hedgehog signaling initiates retinal differentiation. A model is presented for regulation of the Cullin-3 and Cullin-1 pathways that modifies Hedgehog signaling as the morphogenetic furrow moves and the responses of retinal cells change.

Original languageEnglish (US)
Pages (from-to)356-366
Number of pages11
JournalDevelopmental Biology
Volume335
Issue number2
DOIs
StatePublished - Nov 15 2009

Keywords

  • Cubitus Interruptus
  • Drosophila eye
  • EGF receptor
  • Hedgehog
  • Morphogenetic furrow
  • Signal transduction

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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