Regulation of hematopoiesis by growth factors

E. Richard Stanley

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The history of the role of hematopoietic growth factors (HGFs) in the regulation of hematopoiesis is briefly reviewed, commencing with the studies that defined the hematopoietic stem cell and led to the development of in vitro assays for HGFs. The nature of HGF synergism and the underlying mechanisms, as well as the "permissive" versus "instructive" models of HGF action, are also discussed. In addition, work on one of the HGFs, colony stimulating factor-1 (CSF-1), is reviewed, including its function in development as revealed by studies of mouse mutants and its role in innate immunity, inflammatory disease and cancer.

Original languageEnglish (US)
Title of host publicationStem Cells and their Potential for Clinical Application
Pages63-75
Number of pages13
StatePublished - Dec 1 2006

Publication series

NameNATO Security through Science Series B: Physics and Biophysics
ISSN (Print)1871-465X

Keywords

  • Blood cells
  • CSF-1
  • Macrophages
  • Osteoclasts
  • Review

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Nuclear and High Energy Physics
  • Physics and Astronomy (miscellaneous)

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  • Cite this

    Stanley, E. R. (2006). Regulation of hematopoiesis by growth factors. In Stem Cells and their Potential for Clinical Application (pp. 63-75). (NATO Security through Science Series B: Physics and Biophysics).