Regulation of class IA PI3Ks

H. Wu, Y. Yan, Jonathan M. Backer

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Class IA PI3KS (phosphoinositide 3-kinases) regulate a wide range of cellular responses through the production of PI(3,4,5)P3 (phosphatidylinositol 3,4,5-trisphosphate) in cellular membranes. They are activated by receptor tyrosine kinases, by Ras and Rho family GTPases, and in some cases by Gβγ subunits from trimeric G-proteins. Crystallographic studies on the related class IB PI3Kγ, and biochemical and structural studies on the class IA PI3Ks, have led to new insights into how these critical enzymes are regulated in normal cells and how mutations can lead to their constitutive activation in transformed cells. The present paper will discuss recent studies on the regulation of class I (p85/p110) PI3Ks, with a focus on the role of SH2 domains (Src homology 2 domains) in the p85 regulatory subunit in modulating PI3K activity.

Original languageEnglish (US)
Pages (from-to)242-244
Number of pages3
JournalBiochemical Society Transactions
Volume35
Issue number2
DOIs
StatePublished - Apr 2007

Fingerprint

Phosphatidylinositol 3-Kinases
src Homology Domains
rho GTP-Binding Proteins
1-Phosphatidylinositol 4-Kinase
GTP Phosphohydrolases
Receptor Protein-Tyrosine Kinases
Phosphatidylinositols
GTP-Binding Proteins
Phosphotransferases
Chemical activation
Membranes
Mutation
Enzymes

Keywords

  • Adaptor-binding domain (ABD)
  • Breakpoint cluster region (BCR)
  • Domain structure
  • p85
  • Phosphoinositide 3-kinase (PI3K)
  • Src homology 2 domain (SH2 domain)

ASJC Scopus subject areas

  • Biochemistry

Cite this

Regulation of class IA PI3Ks. / Wu, H.; Yan, Y.; Backer, Jonathan M.

In: Biochemical Society Transactions, Vol. 35, No. 2, 04.2007, p. 242-244.

Research output: Contribution to journalArticle

Wu, H. ; Yan, Y. ; Backer, Jonathan M. / Regulation of class IA PI3Ks. In: Biochemical Society Transactions. 2007 ; Vol. 35, No. 2. pp. 242-244.
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