Regression of melanoma, but not keratoacanthoma, is associated with increased HLA-B22 and decreased HLA-B27 and HLA-DR1

M. A. Lowes, H. Dunckley, N. Watson, K. Crotty, B. Cooke, R. St C. Barnetson, G. M. Halliday

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Sixty three Caucasian patients with either melanoma, keratoacanthoma or squamous cell carcinoma were human leucocyte antigen (HLA) typed. The regressing tumour groups were compared with their non-regressing counterparts, and the patient groups were compared with a control Caucasian population. Melanoma patients showing histological regression were more likely to be HLA-B22 positive, and HLA-B27 and -DR1 negative, than those without features of regression. When compared with a control population, the group of melanoma patients were more likely to be HLA-B22 positive. Comparison of the group of keratoacanthomas, a self-regressing tumour, and the group of squamous cell carcinomas, a non-regressing tumour, did not show any significant differences in HLA typing.

Original languageEnglish (US)
Pages (from-to)539-544
Number of pages6
JournalMelanoma Research
Volume9
Issue number6
DOIs
StatePublished - Jan 1 1999

Keywords

  • HLA-B22
  • HLA-B27
  • HLA-DR1
  • Skin cancer
  • Tumour regression

ASJC Scopus subject areas

  • Oncology
  • Dermatology
  • Cancer Research

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