Regression of melanoma, but not keratoacanthoma, is associated with increased HLA-B22 and decreased HLA-B27 and HLA-DR1

M. A. Lowes, H. Dunckley, N. Watson, K. Crotty, B. Cooke, R. St C Barnetson, G. M. Halliday

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Sixty three Caucasian patients with either melanoma, keratoacanthoma or squamous cell carcinoma were human leucocyte antigen (HLA) typed. The regressing tumour groups were compared with their non-regressing counterparts, and the patient groups were compared with a control Caucasian population. Melanoma patients showing histological regression were more likely to be HLA-B22 positive, and HLA-B27 and -DR1 negative, than those without features of regression. When compared with a control population, the group of melanoma patients were more likely to be HLA-B22 positive. Comparison of the group of keratoacanthomas, a self-regressing tumour, and the group of squamous cell carcinomas, a non-regressing tumour, did not show any significant differences in HLA typing.

Original languageEnglish (US)
Pages (from-to)539-544
Number of pages6
JournalMelanoma Research
Volume9
Issue number6
StatePublished - 1999
Externally publishedYes

Fingerprint

Keratoacanthoma
HLA Antigens
Melanoma
Squamous Cell Carcinoma
Neoplasms
Population Groups
Control Groups
Population

Keywords

  • HLA-B22
  • HLA-B27
  • HLA-DR1
  • Skin cancer
  • Tumour regression

ASJC Scopus subject areas

  • Cancer Research
  • Dermatology

Cite this

Lowes, M. A., Dunckley, H., Watson, N., Crotty, K., Cooke, B., Barnetson, R. S. C., & Halliday, G. M. (1999). Regression of melanoma, but not keratoacanthoma, is associated with increased HLA-B22 and decreased HLA-B27 and HLA-DR1. Melanoma Research, 9(6), 539-544.

Regression of melanoma, but not keratoacanthoma, is associated with increased HLA-B22 and decreased HLA-B27 and HLA-DR1. / Lowes, M. A.; Dunckley, H.; Watson, N.; Crotty, K.; Cooke, B.; Barnetson, R. St C; Halliday, G. M.

In: Melanoma Research, Vol. 9, No. 6, 1999, p. 539-544.

Research output: Contribution to journalArticle

Lowes, MA, Dunckley, H, Watson, N, Crotty, K, Cooke, B, Barnetson, RSC & Halliday, GM 1999, 'Regression of melanoma, but not keratoacanthoma, is associated with increased HLA-B22 and decreased HLA-B27 and HLA-DR1', Melanoma Research, vol. 9, no. 6, pp. 539-544.
Lowes MA, Dunckley H, Watson N, Crotty K, Cooke B, Barnetson RSC et al. Regression of melanoma, but not keratoacanthoma, is associated with increased HLA-B22 and decreased HLA-B27 and HLA-DR1. Melanoma Research. 1999;9(6):539-544.
Lowes, M. A. ; Dunckley, H. ; Watson, N. ; Crotty, K. ; Cooke, B. ; Barnetson, R. St C ; Halliday, G. M. / Regression of melanoma, but not keratoacanthoma, is associated with increased HLA-B22 and decreased HLA-B27 and HLA-DR1. In: Melanoma Research. 1999 ; Vol. 9, No. 6. pp. 539-544.
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