Regional metabolite T2 in the healthy rhesus macaque brain at 7T

Songtao Liu, Oded Gonen, Lazar Fleysher, Roman Fleysher, Brian J. Soher, Sarah Pilkenton, Margaret R. Lentz, Eva Maria Ratai, R. Gilberto González

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Although the rhesus macaque brain is an excellent model system for the study of neurological diseases and their responses to treatment, its small size requires much higher spatial resolution, motivating use of ultra-high-field (B0) imagers. Their weaker radio-frequency fields, however, dictate longer pulses; hence longer TE localization sequences. Due to the shorter transverse relaxation time (T2) at higher B0s, these longer TEs subject metabolites to T2-weighting, that decrease their quantification accuracy. To address this we measured the T2s of N-acetylaspartate (NAA), choline (Cho), and creatine (Cr) in several gray matter (GM) and white matter (WM) regions of four healthy rhesus macaques at 7T using three-dimensional (3D) proton MR spectroscopic imaging at (0.4 cm)3 = 64 μl spatial resolution. The results show that macaque T2s are in good agreement with those reported in humans at 7T: 169 ± 2.3 ms for NAA (mean ± SEM), 114 ± 1.9 ms for Cr, and 128 ± 2.4 ms for Cho, with no significant differences between GM and WM. The T2 histograms from 320 voxels in each animal for NAA, Cr, and Cho were similar in position and shape, indicating that they are potentially characteristic of "healthy" in this species.

Original languageEnglish (US)
Pages (from-to)1165-1169
Number of pages5
JournalMagnetic Resonance in Medicine
Volume59
Issue number5
DOIs
StatePublished - May 2008

Keywords

  • Animal models
  • Brain metabolites, 7 tesla
  • MR spectroscopic imaging
  • Rhesus macaque
  • Transverse relaxation time

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Liu, S., Gonen, O., Fleysher, L., Fleysher, R., Soher, B. J., Pilkenton, S., Lentz, M. R., Ratai, E. M., & González, R. G. (2008). Regional metabolite T2 in the healthy rhesus macaque brain at 7T. Magnetic Resonance in Medicine, 59(5), 1165-1169. https://doi.org/10.1002/mrm.21574