Reduced susceptibility to seizures in carbonic anhydrase II deficient mutant mice

Libor Velišek, Solomon L. Moshe, Shu Guang Xu, Wendy Cammer

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The seizure susceptibility of carbonic anhydrase II (CA) deficient mice and their normal littermates was determined and compared. In flurothyl-induced seizures, CA deficient mice displayed longer latencies to the onset of both clonic and tonic-clonic seizures. In pentylenetetrazole-induced seizures mutant mice exhibited a lower incidence of clonic seizures than did their normal littermates. Acetazolamide (a CA blocker) was used for the pretreatment of normal mice to compare them to CA deficient littermates. The pretreated mice displayed a lower incidence of flurothyl-induced tonic-clonic seizures and af both types of pentylenetetrazole seizures. The attempts to elicit audiogenic seizure did not reveal any difference between normal and mutant littermates. However, when the mice were primed by a loud sound during the critical period and retested for audiogenic seizures again at age 1.5 months, the CA deficient mice displayed a significantly lower incidence of seizures. The similarity between the anticonvulsant action of CA deficiency and the anticonvulsant action of acetazolamide suggests an important role of CA in seizures. The exact mechanism of anticonvulsant action by CA inhibition, however, remains to be elucidated.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalEpilepsy Research
Volume14
Issue number2
DOIs
StatePublished - Feb 1993

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Keywords

  • Acetazolamide
  • Carbonic anhydrase
  • Mutant mice
  • Seizures

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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