Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase

Pe'er Dar, Dvora Strassburger, Aviv Shaish, Hannah Levkovitz, Reuvit Halperin, Dror Harats

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

15-Lipoxygenase (15-LOX) is a lipid-oxidizing enzyme that is involved in cell cycle regulation. To evaluate the effect of 15-LOX on reproduction, we studied transgenic mice that overexpress 15-LOX. The transgene was introduced over the genetic background of the low density lipoprotein receptor deficient mice (LDL-R-/-) and reproduction was compared to LDL-R-/- mice. We found a lower pregnancy rate in the 15-LOX/LDL-R-/- mice as compared to the LDL-R-/- mice (62.74 vs. 79.1%, p < 0.01). Additionally, a remarkably higher number of resorptions per pregnancy was found in the 15-LOX/LDL-R-/- mice (16.7 vs. 3.27%, p < 0.001) and it was accompanied by a significantly higher activity of the 15-LOX enzyme in these resorptions as compared to other tissues. These findings may implicate a role for 15-LOX in the development of spontaneous abortions.

Original languageEnglish (US)
Pages (from-to)18-21
Number of pages4
JournalGynecologic and Obstetric Investigation
Volume52
Issue number1
DOIs
StatePublished - 2001

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Arachidonate 15-Lipoxygenase
Induced Abortion
Transgenic Mice
Reproduction
LDL Receptors
Spontaneous Abortion
Enzymes
Pregnancy Rate
Transgenes
Cell Cycle
Lipids

Keywords

  • 15-Lipoxygenase
  • Oxidized LDL
  • Reproduction
  • Spontaneous abortions
  • Transgenic mice

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase. / Dar, Pe'er; Strassburger, Dvora; Shaish, Aviv; Levkovitz, Hannah; Halperin, Reuvit; Harats, Dror.

In: Gynecologic and Obstetric Investigation, Vol. 52, No. 1, 2001, p. 18-21.

Research output: Contribution to journalArticle

Dar, Pe'er ; Strassburger, Dvora ; Shaish, Aviv ; Levkovitz, Hannah ; Halperin, Reuvit ; Harats, Dror. / Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase. In: Gynecologic and Obstetric Investigation. 2001 ; Vol. 52, No. 1. pp. 18-21.
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AU - Harats, Dror

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