Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase

Peer Dar, Dvora Strassburger, Aviv Shaish, Hannah Levkovitz, Reuvit Halperin, Dror Harats

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

15-Lipoxygenase (15-LOX) is a lipid-oxidizing enzyme that is involved in cell cycle regulation. To evaluate the effect of 15-LOX on reproduction, we studied transgenic mice that overexpress 15-LOX. The transgene was introduced over the genetic background of the low density lipoprotein receptor deficient mice (LDL-R-/-) and reproduction was compared to LDL-R-/- mice. We found a lower pregnancy rate in the 15-LOX/LDL-R-/- mice as compared to the LDL-R-/- mice (62.74 vs. 79.1%, p < 0.01). Additionally, a remarkably higher number of resorptions per pregnancy was found in the 15-LOX/LDL-R-/- mice (16.7 vs. 3.27%, p < 0.001) and it was accompanied by a significantly higher activity of the 15-LOX enzyme in these resorptions as compared to other tissues. These findings may implicate a role for 15-LOX in the development of spontaneous abortions.

Original languageEnglish (US)
Pages (from-to)18-21
Number of pages4
JournalGynecologic and Obstetric Investigation
Volume52
Issue number1
DOIs
StatePublished - Sep 21 2001

Keywords

  • 15-Lipoxygenase
  • Oxidized LDL
  • Reproduction
  • Spontaneous abortions
  • Transgenic mice

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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