Recurrent status epilepticus in children

Shlomo Shinnar, Joseph Maytal, Lawrence Krasnoff, Solomon L. Moshe

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Abstract

Status epilepticus is an uncommon but life-threatening seizure. Little is known about the risk of recurrent status epilepticus in patients who present with an initial episode. To determine the risk of recurrent status epilepticus in children, we prospectively followed 95 children, identified at the time of their first episode of status epilepticus, for a mean of 29.0 months (range, 4-60 months). The patients' ages ranged from 1 month to 18 years (mean, 4.6 years). The cause of the status epilepticus was classified as idiopathic (n = 24), remote symptomatic (n = 18), febrile (n = 29), acute symptomatic (n = 18), or progressive neurological disorder (n = 6). Sixteen children (17%) had at least 2 episodes of status epilepticus. The risk of recurrent status was 4% (n = 1) in the idiopathic group, 44% (n = 8) in the remote symptomatic group, 3% (n = 1) in the febrile group, 11% (n = 2) in the acute symptomatic group, and 67% (n = 4) in those with progressive neurological disease. Recurrent status epilepticus occurred primarily in neurologically abnormal children. While neurologically abnormal children accounted for 34% (n = 32) of all children with status epilepticus, they comprised 88% (n = 14) of the children with recurrent status epilepticus (p < 0.001) and all 5 of the children with multiple (≥ 3) episodes of status (p < 0.001). Fifteen of 16 children with recurrent status epilepticus were being treated with antiepileptic drugs at the time of recurrence. The morbidity and mortality of status epilepticus were low. No child had a measurable deterioration in neurological function following a subsequent episode of status epilepticus. Recurrent status epilepticus occurs primarily in children with an underlying neurological abnormality. Status epilepticus reoccurs in this group despite conventional antiepileptic drug therapy.

Original languageEnglish (US)
Pages (from-to)598-604
Number of pages7
JournalAnnals of Neurology
Volume31
Issue number6
StatePublished - Jun 1992

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Status Epilepticus
Anticonvulsants
Fever
Nervous System Diseases
Seizures

ASJC Scopus subject areas

  • Neuroscience(all)

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Recurrent status epilepticus in children. / Shinnar, Shlomo; Maytal, Joseph; Krasnoff, Lawrence; Moshe, Solomon L.

In: Annals of Neurology, Vol. 31, No. 6, 06.1992, p. 598-604.

Research output: Contribution to journalArticle

Shinnar, S, Maytal, J, Krasnoff, L & Moshe, SL 1992, 'Recurrent status epilepticus in children', Annals of Neurology, vol. 31, no. 6, pp. 598-604.
Shinnar, Shlomo ; Maytal, Joseph ; Krasnoff, Lawrence ; Moshe, Solomon L. / Recurrent status epilepticus in children. In: Annals of Neurology. 1992 ; Vol. 31, No. 6. pp. 598-604.
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