Recognition and stabilization of quadruplex DNA by a potent new telomerase inhibitor: NMR studies of the 2:1 complex of a pentacyclic methylacridinium cation with d(TTAGGGT)4

Evripidis Gavathiotis, Robert A. Heald, Malcolm F.G. Stevens, Mark S. Searle

76 Scopus citations

Abstract

Guided by 24 drug-DNA NOEs, the complex formed between RHPS4 (a novel fluorinated polycyclic methylacridinium salt with potent telomerase activity) and d(TTAGGGT)4 has been modeled by using MD simulations with drug molecules intercalated at the ApG and GpT steps. A low-energy structure for the 2:1 complex has a partial positive charge on the acridine 13-N atom (which acts as a pseudo potassium ion) positioned above the center of the G-tetrad (see picture).

Original languageEnglish (US)
Pages (from-to)4749-4751
Number of pages3
JournalAngewandte Chemie - International Edition
Volume40
Issue number24
DOIs
Publication statusPublished - Dec 17 2001
Externally publishedYes

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Keywords

  • DNA recognition
  • G-quadruplex
  • NMR spectroscopy
  • Telomerase

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Recognition and stabilization of quadruplex DNA by a potent new telomerase inhibitor : NMR studies of the 2:1 complex of a pentacyclic methylacridinium cation with d(TTAGGGT)4. / Gavathiotis, Evripidis; Heald, Robert A.; Stevens, Malcolm F.G.; Searle, Mark S.

In: Angewandte Chemie - International Edition, Vol. 40, No. 24, 17.12.2001, p. 4749-4751.

Research output: Contribution to journalArticle