Radiofrequency ablation after breast lumpectomy added to extend intraoperative margins in the treatment of breast cancer (ABLATE): A single-institution experience

Aimee MacKey, Sheldon Feldman, Amiya Vaz, Lara Durrant, Christopher Seaton, V. Suzanne Klimberg

Research output: Contribution to journalArticle

4 Scopus citations


Background: Breast-conserving surgery is often preferred to treat early-stage breast cancer. This method aims to minimize repeat excision and local recurrence rates. The ABLATE Registry expands this to multiple centers with a total accrual goal of 250. This video illustrates an intraoperative radiofrequency ablation (RFA) technique. Methods: Sixteen women with a mean age of 65 years underwent RFA after lumpectomy. The RFA probe was deployed 1 cm circumferentially in the cavity and maintained at 100°C for 15 min. The ablation zone was monitored with color-flow ultrasound. Patients returned 2 weeks later to complete the Subjective Cosmetic Scale and the European Organisation for Research and Treatment of Cancer Body Image Scale. Results: At a mean follow-up of 3.9 months, there were no local recurrences. Two-week cosmesis scores were excellent (n = 9) or good (n = 5). Conclusions: Our initial experience is encouraging. Continued national accrual will permit evaluation of reduction in repeat excision and local recurrence rate, as well as potentially reduce requirements for adjuvant radiation.

Original languageEnglish (US)
Pages (from-to)2618-2619
Number of pages2
JournalAnnals of Surgical Oncology
Issue number8
Publication statusPublished - Aug 1 2012
Externally publishedYes


ASJC Scopus subject areas

  • Surgery
  • Oncology

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