Radiation-induced tumors in irradiated stage I testicular seminoma

Results of a 25-year follow-up (1968-1993)

Moshe E. Stein, Michelle Leviov, Keren Drumea, Boaz Moshkovitz, Ofer Nativ, David M. Milstein, Edmond Sabo, Abraham Kuten

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and Objectives: Testicular seminoma is a very radiosensitive and curable cancer, with survival rates following radiation therapy within the range of 90-98% without apparent severe side effects. However, long-term survival following exposure to moderate-dose radiation therapy can result in radiation-induced tumors. Methods: The incidence of radiation-induced tumors was determined in 81 irradiated stage I testicular seminoma patients treated at the Northern Israel Oncology Center (NIOC) from 1968 through 1993. Results: Three (4%) patients developed second cancers within the high-dose volume. Indeed, those patients received a higher than usual dose to the para- aortic and pelvic regions. One patient, who developed inoperable pancreatic carcinoma, was treated with 'hockey stick' field and mediastinal irradiation, plus, as a result of relapses, multiple cisplatin and VP-16 based regimens. Conclusions: The elimination of causative factors through lower total doses and field size reduction may reduce the, albeit very low, incidence of radiation-induced cancer in cured testicular seminoma.

Original languageEnglish (US)
Pages (from-to)38-40
Number of pages3
JournalJournal of Surgical Oncology
Volume67
Issue number1
DOIs
StatePublished - Jan 1998
Externally publishedYes

Fingerprint

Seminoma
Radiation
Neoplasms
Radiotherapy
Radiation-Induced Neoplasms
Hockey
Second Primary Neoplasms
Incidence
Etoposide
Israel
Pelvis
Cisplatin
Survival Rate
Recurrence
Survival

Keywords

  • Induced tumors
  • Radiotherapy
  • Stage I
  • Testicular seminoma

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Radiation-induced tumors in irradiated stage I testicular seminoma : Results of a 25-year follow-up (1968-1993). / Stein, Moshe E.; Leviov, Michelle; Drumea, Keren; Moshkovitz, Boaz; Nativ, Ofer; Milstein, David M.; Sabo, Edmond; Kuten, Abraham.

In: Journal of Surgical Oncology, Vol. 67, No. 1, 01.1998, p. 38-40.

Research output: Contribution to journalArticle

Stein, Moshe E. ; Leviov, Michelle ; Drumea, Keren ; Moshkovitz, Boaz ; Nativ, Ofer ; Milstein, David M. ; Sabo, Edmond ; Kuten, Abraham. / Radiation-induced tumors in irradiated stage I testicular seminoma : Results of a 25-year follow-up (1968-1993). In: Journal of Surgical Oncology. 1998 ; Vol. 67, No. 1. pp. 38-40.
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