Quality of life following amputation or limb preservation in patients with lower extremity bone sarcoma

Gary E. Mason, Lele Aung, Sarah Gall, Paul A. Meyers, Robert Butler, Sarah Krüg, Mimi Kim, John H. Healey, Richard Gorlick

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose: Although functional differences have been described between patients with lower extremity bone sarcoma with amputation and limb-preservation surgery, differences have not clearly been shown between the two groups related to quality of life. The purpose of the study was to determine if there is a difference in overall quality of life in lower extremity bone sarcoma survivors related to whether they had an amputation or a limb-preservation procedure while identifying psychological differences for further evaluation. The main hypothesis was that sparing a person's limb, as opposed to amputating it, would result in a better quality of life. Patients and Methods: Eighty-two long-term survivors of lower extremity bone sarcoma were studied to make a comparison of the overall quality of life, pain assessment, and psychological evaluations in limb preservation and amputation patients. Forty-eight patients with limb preservation and thirty-four patients with amputations were enrolled in the study. Validated psychometric measures including the Quality of Life Questionnaire (QLQ), the Minnesota Multiphasic Personality Inventory, and visual analog scales were utilized. Results: The overall quality of life of patients with limb preservation was significantly higher than patients with amputation (p-value < 0.01). Significant differences were noted in the categories of material well-being, job satisfiers, and occupational relations. Conclusion: The overall quality of life of patients with limb-preservation appears to be better than for those patients with amputation based on the QLQ in patients surviving lower extremity bone sarcoma. Further analysis needs to verify the results and focus on the categories that significantly affect the overall quality of life.

Original languageEnglish (US)
Article number00210
JournalFrontiers in Oncology
Volume3 AUG
DOIs
StatePublished - 2013

Fingerprint

Bones of Lower Extremity
Amputation
Sarcoma
Extremities
Quality of Life
Survivors
Psychology
MMPI
Pain Measurement
Visual Analog Scale
Psychometrics

Keywords

  • Amputation
  • Limb salvage
  • Orthopedic outcomes
  • Quality of life
  • Sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mason, G. E., Aung, L., Gall, S., Meyers, P. A., Butler, R., Krüg, S., ... Gorlick, R. (2013). Quality of life following amputation or limb preservation in patients with lower extremity bone sarcoma. Frontiers in Oncology, 3 AUG, [00210]. https://doi.org/10.3389/fonc.2013.00210

Quality of life following amputation or limb preservation in patients with lower extremity bone sarcoma. / Mason, Gary E.; Aung, Lele; Gall, Sarah; Meyers, Paul A.; Butler, Robert; Krüg, Sarah; Kim, Mimi; Healey, John H.; Gorlick, Richard.

In: Frontiers in Oncology, Vol. 3 AUG, 00210, 2013.

Research output: Contribution to journalArticle

Mason, GE, Aung, L, Gall, S, Meyers, PA, Butler, R, Krüg, S, Kim, M, Healey, JH & Gorlick, R 2013, 'Quality of life following amputation or limb preservation in patients with lower extremity bone sarcoma', Frontiers in Oncology, vol. 3 AUG, 00210. https://doi.org/10.3389/fonc.2013.00210
Mason, Gary E. ; Aung, Lele ; Gall, Sarah ; Meyers, Paul A. ; Butler, Robert ; Krüg, Sarah ; Kim, Mimi ; Healey, John H. ; Gorlick, Richard. / Quality of life following amputation or limb preservation in patients with lower extremity bone sarcoma. In: Frontiers in Oncology. 2013 ; Vol. 3 AUG.
@article{bb720947cd594c95a8572bb46b3c2a8b,
title = "Quality of life following amputation or limb preservation in patients with lower extremity bone sarcoma",
abstract = "Purpose: Although functional differences have been described between patients with lower extremity bone sarcoma with amputation and limb-preservation surgery, differences have not clearly been shown between the two groups related to quality of life. The purpose of the study was to determine if there is a difference in overall quality of life in lower extremity bone sarcoma survivors related to whether they had an amputation or a limb-preservation procedure while identifying psychological differences for further evaluation. The main hypothesis was that sparing a person's limb, as opposed to amputating it, would result in a better quality of life. Patients and Methods: Eighty-two long-term survivors of lower extremity bone sarcoma were studied to make a comparison of the overall quality of life, pain assessment, and psychological evaluations in limb preservation and amputation patients. Forty-eight patients with limb preservation and thirty-four patients with amputations were enrolled in the study. Validated psychometric measures including the Quality of Life Questionnaire (QLQ), the Minnesota Multiphasic Personality Inventory, and visual analog scales were utilized. Results: The overall quality of life of patients with limb preservation was significantly higher than patients with amputation (p-value < 0.01). Significant differences were noted in the categories of material well-being, job satisfiers, and occupational relations. Conclusion: The overall quality of life of patients with limb-preservation appears to be better than for those patients with amputation based on the QLQ in patients surviving lower extremity bone sarcoma. Further analysis needs to verify the results and focus on the categories that significantly affect the overall quality of life.",
keywords = "Amputation, Limb salvage, Orthopedic outcomes, Quality of life, Sarcoma",
author = "Mason, {Gary E.} and Lele Aung and Sarah Gall and Meyers, {Paul A.} and Robert Butler and Sarah Kr{\"u}g and Mimi Kim and Healey, {John H.} and Richard Gorlick",
year = "2013",
doi = "10.3389/fonc.2013.00210",
language = "English (US)",
volume = "3 AUG",
journal = "Frontiers in Oncology",
issn = "2234-943X",
publisher = "Frontiers Media S. A.",

}

TY - JOUR

T1 - Quality of life following amputation or limb preservation in patients with lower extremity bone sarcoma

AU - Mason, Gary E.

AU - Aung, Lele

AU - Gall, Sarah

AU - Meyers, Paul A.

AU - Butler, Robert

AU - Krüg, Sarah

AU - Kim, Mimi

AU - Healey, John H.

AU - Gorlick, Richard

PY - 2013

Y1 - 2013

N2 - Purpose: Although functional differences have been described between patients with lower extremity bone sarcoma with amputation and limb-preservation surgery, differences have not clearly been shown between the two groups related to quality of life. The purpose of the study was to determine if there is a difference in overall quality of life in lower extremity bone sarcoma survivors related to whether they had an amputation or a limb-preservation procedure while identifying psychological differences for further evaluation. The main hypothesis was that sparing a person's limb, as opposed to amputating it, would result in a better quality of life. Patients and Methods: Eighty-two long-term survivors of lower extremity bone sarcoma were studied to make a comparison of the overall quality of life, pain assessment, and psychological evaluations in limb preservation and amputation patients. Forty-eight patients with limb preservation and thirty-four patients with amputations were enrolled in the study. Validated psychometric measures including the Quality of Life Questionnaire (QLQ), the Minnesota Multiphasic Personality Inventory, and visual analog scales were utilized. Results: The overall quality of life of patients with limb preservation was significantly higher than patients with amputation (p-value < 0.01). Significant differences were noted in the categories of material well-being, job satisfiers, and occupational relations. Conclusion: The overall quality of life of patients with limb-preservation appears to be better than for those patients with amputation based on the QLQ in patients surviving lower extremity bone sarcoma. Further analysis needs to verify the results and focus on the categories that significantly affect the overall quality of life.

AB - Purpose: Although functional differences have been described between patients with lower extremity bone sarcoma with amputation and limb-preservation surgery, differences have not clearly been shown between the two groups related to quality of life. The purpose of the study was to determine if there is a difference in overall quality of life in lower extremity bone sarcoma survivors related to whether they had an amputation or a limb-preservation procedure while identifying psychological differences for further evaluation. The main hypothesis was that sparing a person's limb, as opposed to amputating it, would result in a better quality of life. Patients and Methods: Eighty-two long-term survivors of lower extremity bone sarcoma were studied to make a comparison of the overall quality of life, pain assessment, and psychological evaluations in limb preservation and amputation patients. Forty-eight patients with limb preservation and thirty-four patients with amputations were enrolled in the study. Validated psychometric measures including the Quality of Life Questionnaire (QLQ), the Minnesota Multiphasic Personality Inventory, and visual analog scales were utilized. Results: The overall quality of life of patients with limb preservation was significantly higher than patients with amputation (p-value < 0.01). Significant differences were noted in the categories of material well-being, job satisfiers, and occupational relations. Conclusion: The overall quality of life of patients with limb-preservation appears to be better than for those patients with amputation based on the QLQ in patients surviving lower extremity bone sarcoma. Further analysis needs to verify the results and focus on the categories that significantly affect the overall quality of life.

KW - Amputation

KW - Limb salvage

KW - Orthopedic outcomes

KW - Quality of life

KW - Sarcoma

UR - http://www.scopus.com/inward/record.url?scp=84891078887&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891078887&partnerID=8YFLogxK

U2 - 10.3389/fonc.2013.00210

DO - 10.3389/fonc.2013.00210

M3 - Article

AN - SCOPUS:84891078887

VL - 3 AUG

JO - Frontiers in Oncology

JF - Frontiers in Oncology

SN - 2234-943X

M1 - 00210

ER -