Pyrimidine salvage pathway in Mycobacterium tuberculosis

A. D. Villela, Z. A. Sánchez-Quitian, Rodrigo G. Ducati, D. S. Santos, L. A. Basso

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The causative agent of tuberculosis (TB), Mycobacterium tuberculosis, infects one-third of the world population. TB remains the leading cause of mortality due to a single bacterial pathogen. The worldwide increase in incidence of M. tuberculosis has been attributed to the high proliferation rates of multi and extensively drug-resistant strains, and to co-infection with the human immunodeficiency virus. There is thus a continuous requirement for studies on mycobacterial metabolism to identify promising targets for the development of new agents to combat TB. Singular characteristics of this pathogen, such as functional and structural features of enzymes involved in fundamental metabolic pathways, can be evaluated to identify possible targets for drug development. Enzymes involved in the pyrimidine salvage pathway might be attractive targets for rational drug design against TB, since this pathway is vital for all bacterial cells, and is composed of enzymes considerably different from those present in humans. Moreover, the enzymes of the pyrimidine salvage pathway might have an important role in the mycobacterial latent state, since M. tuberculosis has to recycle bases and/or nucleosides to survive in the hostile environment imposed by the host. The present review describes the enzymes of M. tuberculosis pyrimidine salvage pathway as attractive targets for the development of new antimycobacterial agents. Enzyme functional and structural data have been included to provide a broader knowledge on which to base the search for compounds with selective biological activity.

Original languageEnglish (US)
Pages (from-to)1286-1298
Number of pages13
JournalCurrent Medicinal Chemistry
Volume18
Issue number9
DOIs
StatePublished - Mar 2011
Externally publishedYes

Fingerprint

Salvaging
Mycobacterium tuberculosis
Tuberculosis
Enzymes
Pathogens
Pharmaceutical Preparations
Drug Design
Metabolic Networks and Pathways
Bioactivity
Coinfection
Viruses
Nucleosides
Metabolism
pyrimidine
HIV
Anti-Bacterial Agents
Mortality
Incidence
Population

Keywords

  • Enzyme functional features
  • Enzyme structural features
  • Mycobacterium tuberculosis
  • Pyrimidine salvage pathway
  • Rational drug design
  • Tuberculosis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Villela, A. D., Sánchez-Quitian, Z. A., Ducati, R. G., Santos, D. S., & Basso, L. A. (2011). Pyrimidine salvage pathway in Mycobacterium tuberculosis. Current Medicinal Chemistry, 18(9), 1286-1298. https://doi.org/10.2174/092986711795029555

Pyrimidine salvage pathway in Mycobacterium tuberculosis. / Villela, A. D.; Sánchez-Quitian, Z. A.; Ducati, Rodrigo G.; Santos, D. S.; Basso, L. A.

In: Current Medicinal Chemistry, Vol. 18, No. 9, 03.2011, p. 1286-1298.

Research output: Contribution to journalArticle

Villela, AD, Sánchez-Quitian, ZA, Ducati, RG, Santos, DS & Basso, LA 2011, 'Pyrimidine salvage pathway in Mycobacterium tuberculosis', Current Medicinal Chemistry, vol. 18, no. 9, pp. 1286-1298. https://doi.org/10.2174/092986711795029555
Villela AD, Sánchez-Quitian ZA, Ducati RG, Santos DS, Basso LA. Pyrimidine salvage pathway in Mycobacterium tuberculosis. Current Medicinal Chemistry. 2011 Mar;18(9):1286-1298. https://doi.org/10.2174/092986711795029555
Villela, A. D. ; Sánchez-Quitian, Z. A. ; Ducati, Rodrigo G. ; Santos, D. S. ; Basso, L. A. / Pyrimidine salvage pathway in Mycobacterium tuberculosis. In: Current Medicinal Chemistry. 2011 ; Vol. 18, No. 9. pp. 1286-1298.
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