Pulsatile machine perfusion with vasosol solution improves early graft function after cadaveric renal transplantation (Retraction in

Transplantation (2005) 79:12 (1774))

James V. Guarrera, Maximilian Polyak, Ben O Mar Arrington, Sandip Kapur, William T. Stubenbord, Milan Kinkhabwala

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background. Cold storage is the most common method of preservation in renal transplantation, but pulsatile machine perfusion (MP) is increasingly used for purposes of ex vivo assessment and resuscitation of high risk allografts. Vasosol (VSL) MP solution (MPS) (Pike Laboratories Inc, Eagle, PA) is a novel perfusate with enhanced vasodilatory and antioxidant capacity. We report our experience with VSL in machine preservation of renal allografts. Methods. Locally procured cadaver kidney pairs undergoing MP were randomized to VSL or control solution (Belzer MPS; Trans-Med, Elk River, MN). En bloc perfusion was performed according to standard MP procedures. Transplantation was performed at 1 of 12 local transplant centers. Donor and recipient data were collected prospectively. Results. Data from 162 transplanted kidneys were analyzed. A total of 82 renal grafts were perfused with VSL, and 80 were perfused with control solution. No organs were lost secondary to the technique of MP. There was no difference in donor or recipient age between groups. Kidneys perfused with VSL exhibited significantly higher rates of immediate function and significantly less delayed graft function (12.2% vs. 21.2%). Discharge creatinine and length of stay were also significantly improved in the VSL group. One-year graft and patient survivals were equivalent (95%) in both groups. Conclusions. VSL improved early graft function and shortened the length of stay compared with Belzer MPS. Further improvement in preservation solutions in conjunction with pulsatile perfusion shows promise in improving early outcomes after renal transplantation, especially for extended criteria donor kidneys.

Original languageEnglish (US)
Pages (from-to)1264-1268
Number of pages5
JournalTransplantation
Volume77
Issue number8
StatePublished - Apr 27 2004
Externally publishedYes

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Pulsatile Flow
Kidney Transplantation
Transplantation
Transplants
Kidney
Perfusion
Tissue Donors
Allografts
Length of Stay
Esocidae
Delayed Graft Function
Eagles
Graft Survival
Cadaver
Rivers
Resuscitation
Creatinine
Age Groups
Antioxidants

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Pulsatile machine perfusion with vasosol solution improves early graft function after cadaveric renal transplantation (Retraction in : Transplantation (2005) 79:12 (1774)). / Guarrera, James V.; Polyak, Maximilian; Arrington, Ben O Mar; Kapur, Sandip; Stubenbord, William T.; Kinkhabwala, Milan.

In: Transplantation, Vol. 77, No. 8, 27.04.2004, p. 1264-1268.

Research output: Contribution to journalArticle

Guarrera, James V. ; Polyak, Maximilian ; Arrington, Ben O Mar ; Kapur, Sandip ; Stubenbord, William T. ; Kinkhabwala, Milan. / Pulsatile machine perfusion with vasosol solution improves early graft function after cadaveric renal transplantation (Retraction in : Transplantation (2005) 79:12 (1774)). In: Transplantation. 2004 ; Vol. 77, No. 8. pp. 1264-1268.
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abstract = "Background. Cold storage is the most common method of preservation in renal transplantation, but pulsatile machine perfusion (MP) is increasingly used for purposes of ex vivo assessment and resuscitation of high risk allografts. Vasosol (VSL) MP solution (MPS) (Pike Laboratories Inc, Eagle, PA) is a novel perfusate with enhanced vasodilatory and antioxidant capacity. We report our experience with VSL in machine preservation of renal allografts. Methods. Locally procured cadaver kidney pairs undergoing MP were randomized to VSL or control solution (Belzer MPS; Trans-Med, Elk River, MN). En bloc perfusion was performed according to standard MP procedures. Transplantation was performed at 1 of 12 local transplant centers. Donor and recipient data were collected prospectively. Results. Data from 162 transplanted kidneys were analyzed. A total of 82 renal grafts were perfused with VSL, and 80 were perfused with control solution. No organs were lost secondary to the technique of MP. There was no difference in donor or recipient age between groups. Kidneys perfused with VSL exhibited significantly higher rates of immediate function and significantly less delayed graft function (12.2{\%} vs. 21.2{\%}). Discharge creatinine and length of stay were also significantly improved in the VSL group. One-year graft and patient survivals were equivalent (95{\%}) in both groups. Conclusions. VSL improved early graft function and shortened the length of stay compared with Belzer MPS. Further improvement in preservation solutions in conjunction with pulsatile perfusion shows promise in improving early outcomes after renal transplantation, especially for extended criteria donor kidneys.",
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