Pulmonary vein calcification by EBCT in patients with drug refractory nonvalular atrial fibrillation

James Adams, Andrea Natale, Claude S. Elayi, Luigi Di Biase, David O. Martin, Salwa Beheiry, Steven Hao, Richard Hongo, Chi Keong Ching

Research output: Contribution to journalArticle

2 Scopus citations


Introduction: Pulmonary veins in patients with atrial fibrillation (AF) have been shown to be highly arrhythmogenic. Calcification in these veins may play an adjunctive role in the pathogenesis of AF. Methods and Results: A case control study was performed in patients with drug refractory nonvalvular AF whose preablation computed tomography chest scans demonstrated pulmonary vein (PV) calcification. Eight out of 48 patients with PV calcification were compared to 50 patients without AF who underwent electron beam computed tomography coronary artery calcium scores. These patients were matched for age, gender, coronary artery calcium scores, and the presence of PV calcification. The mean age of the combined group was 57±9 years and 60% were men. The mean total PV calcium score was significantly higher at 199±112 in patients with AF compared to 106±52 in controls (p=0.018). Men had significantly higher total PV calcium score than women in both groups. Conclusion: Total PV calcium score was significantly higher in patients with atrial fibrillation. Increased PV calcification may play an adjunctive role in the pathogenesis in initiating and maintaining AF.

Original languageEnglish (US)
Pages (from-to)173-175
Number of pages3
JournalJournal of Interventional Cardiac Electrophysiology
Issue number3
StatePublished - Sep 1 2008
Externally publishedYes



  • Ablation
  • Atrial fibrillation
  • Calcification
  • Ct scan

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this