Pulmonary vein calcification by EBCT in patients with drug refractory nonvalular atrial fibrillation

James Adams; Andrea Natale; Claude S. Elayi; Luigi Di Biase; David O. Martin; Salwa Beheiry; Steven Hao; Richard Hongo; Chi Keong Ching

doi:10.1007/s10840-008-9262-x

Pulmonary vein calcification by EBCT in patients with drug refractory nonvalular atrial fibrillation

James Adams, Andrea Natale, Claude S. Elayi, Luigi Di Biase, David O. Martin, Salwa Beheiry, Steven Hao, Richard Hongo, Chi Keong Ching

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Introduction: Pulmonary veins in patients with atrial fibrillation (AF) have been shown to be highly arrhythmogenic. Calcification in these veins may play an adjunctive role in the pathogenesis of AF. Methods and Results: A case control study was performed in patients with drug refractory nonvalvular AF whose preablation computed tomography chest scans demonstrated pulmonary vein (PV) calcification. Eight out of 48 patients with PV calcification were compared to 50 patients without AF who underwent electron beam computed tomography coronary artery calcium scores. These patients were matched for age, gender, coronary artery calcium scores, and the presence of PV calcification. The mean age of the combined group was 57±9 years and 60% were men. The mean total PV calcium score was significantly higher at 199±112 in patients with AF compared to 106±52 in controls (p=0.018). Men had significantly higher total PV calcium score than women in both groups. Conclusion: Total PV calcium score was significantly higher in patients with atrial fibrillation. Increased PV calcification may play an adjunctive role in the pathogenesis in initiating and maintaining AF.

Original language	English (US)
Pages (from-to)	173-175
Number of pages	3
Journal	Journal of Interventional Cardiac Electrophysiology
Volume	22
Issue number	3
DOIs	https://doi.org/10.1007/s10840-008-9262-x
State	Published - Sep 2008
Externally published	Yes

Keywords

Ablation
Atrial fibrillation
Calcification
Ct scan

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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title = "Pulmonary vein calcification by EBCT in patients with drug refractory nonvalular atrial fibrillation",

abstract = "Introduction: Pulmonary veins in patients with atrial fibrillation (AF) have been shown to be highly arrhythmogenic. Calcification in these veins may play an adjunctive role in the pathogenesis of AF. Methods and Results: A case control study was performed in patients with drug refractory nonvalvular AF whose preablation computed tomography chest scans demonstrated pulmonary vein (PV) calcification. Eight out of 48 patients with PV calcification were compared to 50 patients without AF who underwent electron beam computed tomography coronary artery calcium scores. These patients were matched for age, gender, coronary artery calcium scores, and the presence of PV calcification. The mean age of the combined group was 57±9 years and 60% were men. The mean total PV calcium score was significantly higher at 199±112 in patients with AF compared to 106±52 in controls (p=0.018). Men had significantly higher total PV calcium score than women in both groups. Conclusion: Total PV calcium score was significantly higher in patients with atrial fibrillation. Increased PV calcification may play an adjunctive role in the pathogenesis in initiating and maintaining AF.",

keywords = "Ablation, Atrial fibrillation, Calcification, Ct scan",

author = "James Adams and Andrea Natale and Elayi, {Claude S.} and {Di Biase}, Luigi and Martin, {David O.} and Salwa Beheiry and Steven Hao and Richard Hongo and Ching, {Chi Keong}",

year = "2008",

month = sep,

doi = "10.1007/s10840-008-9262-x",

language = "English (US)",

volume = "22",

pages = "173--175",

journal = "Journal of Interventional Cardiac Electrophysiology",

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T1 - Pulmonary vein calcification by EBCT in patients with drug refractory nonvalular atrial fibrillation

AU - Adams, James

AU - Natale, Andrea

AU - Elayi, Claude S.

AU - Di Biase, Luigi

AU - Martin, David O.

AU - Beheiry, Salwa

AU - Hao, Steven

AU - Hongo, Richard

AU - Ching, Chi Keong

PY - 2008/9

Y1 - 2008/9

N2 - Introduction: Pulmonary veins in patients with atrial fibrillation (AF) have been shown to be highly arrhythmogenic. Calcification in these veins may play an adjunctive role in the pathogenesis of AF. Methods and Results: A case control study was performed in patients with drug refractory nonvalvular AF whose preablation computed tomography chest scans demonstrated pulmonary vein (PV) calcification. Eight out of 48 patients with PV calcification were compared to 50 patients without AF who underwent electron beam computed tomography coronary artery calcium scores. These patients were matched for age, gender, coronary artery calcium scores, and the presence of PV calcification. The mean age of the combined group was 57±9 years and 60% were men. The mean total PV calcium score was significantly higher at 199±112 in patients with AF compared to 106±52 in controls (p=0.018). Men had significantly higher total PV calcium score than women in both groups. Conclusion: Total PV calcium score was significantly higher in patients with atrial fibrillation. Increased PV calcification may play an adjunctive role in the pathogenesis in initiating and maintaining AF.

AB - Introduction: Pulmonary veins in patients with atrial fibrillation (AF) have been shown to be highly arrhythmogenic. Calcification in these veins may play an adjunctive role in the pathogenesis of AF. Methods and Results: A case control study was performed in patients with drug refractory nonvalvular AF whose preablation computed tomography chest scans demonstrated pulmonary vein (PV) calcification. Eight out of 48 patients with PV calcification were compared to 50 patients without AF who underwent electron beam computed tomography coronary artery calcium scores. These patients were matched for age, gender, coronary artery calcium scores, and the presence of PV calcification. The mean age of the combined group was 57±9 years and 60% were men. The mean total PV calcium score was significantly higher at 199±112 in patients with AF compared to 106±52 in controls (p=0.018). Men had significantly higher total PV calcium score than women in both groups. Conclusion: Total PV calcium score was significantly higher in patients with atrial fibrillation. Increased PV calcification may play an adjunctive role in the pathogenesis in initiating and maintaining AF.

KW - Ablation

KW - Atrial fibrillation

KW - Calcification

KW - Ct scan

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Pulmonary vein calcification by EBCT in patients with drug refractory nonvalular atrial fibrillation

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