Pulmonary Vein Antral Isolation Using an Open Irrigation Ablation Catheter for the Treatment of Atrial Fibrillation. A Randomized Pilot Study

Mohamed H. Kanj, Oussama Wazni, Tamer Fahmy, Sergio Thal, Dimpi Patel, Claude Elay, Luigi Di Biase, Mauricio Arruda, Walid Saliba, Robert A. Schweikert, Jennifer E. Cummings, J. David Burkhardt, David O. Martin, Gemma Pelargonio, Antonio Dello Russo, Michela Casella, Pietro Santarelli, Domenico Potenza, Raffaele Fanelli, Raimondo Massaro & 2 others Giovanni Forleo, Andrea Natale

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Abstract

Objectives: We sought to test how catheter ablation using an open irrigation catheter (OIC) compares with standard catheters for pulmonary vein antrum isolation. Background: Open irrigation catheters have the advantage of delivering greater power without increasing the temperature of the catheter tip, which enables deeper and wider lesions without the formation of coagulum on catheters. Methods: Catheter ablation was performed using an 8-mm catheter (8MC) or an OIC. Patients were randomized to 3 groups: 8MC; OIC-1, OIC with a higher peak power (50 W); and OIC-2, OIC with lower peak power (35 W). Results: A total of 180 patients were randomized to the 3 treatment strategies. Isolation of pulmonary vein antra was achieved in all patients. The freedom from atrial fibrillation was significantly greater in the 8MC and OIC-1 groups compared with the OIC-2 group (78%, 82%, and 68%, respectively, p = 0.043). Fluoroscopy time was lower in OIC-1 compared with OIC-2 and 8MC (28 ± 1 min, 53 ± 2 min, and 46 ± 2 min, respectively, p = 0.001). The mean left atrium instrumentation time was lower in the OIC-1 compared with the OIC-2 and 8MC groups (59 ± 3 min, 90 ± 5 min, and 88 ± 4 min, respectively, p = 0.001). However, there was a greater incidence of "pops" in the OIC-1 (100%, 0%, 0%, p < 0.001) along with higher incidences of pericardial effusion (20%, 0%, 0%, p < 0.001) and gastrointestinal complaints (17% in OIC-1, 3% in 8MC, and 5% in OIC-2, p = 0.031). Conclusions: Although there was a decrease in fluoroscopy and left atrium instrumentation time with the use of OIC at higher power, this setting was associated with increased cardiovascular and gastrointestinal complications.

Original languageEnglish (US)
Pages (from-to)1634-1641
Number of pages8
JournalJournal of the American College of Cardiology
Volume49
Issue number15
DOIs
StatePublished - Apr 17 2007
Externally publishedYes

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Catheter Ablation
Pulmonary Veins
Atrial Fibrillation
Catheters
Therapeutics
Antral
Fluoroscopy
Heart Atria

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Pulmonary Vein Antral Isolation Using an Open Irrigation Ablation Catheter for the Treatment of Atrial Fibrillation. A Randomized Pilot Study. / Kanj, Mohamed H.; Wazni, Oussama; Fahmy, Tamer; Thal, Sergio; Patel, Dimpi; Elay, Claude; Di Biase, Luigi; Arruda, Mauricio; Saliba, Walid; Schweikert, Robert A.; Cummings, Jennifer E.; Burkhardt, J. David; Martin, David O.; Pelargonio, Gemma; Dello Russo, Antonio; Casella, Michela; Santarelli, Pietro; Potenza, Domenico; Fanelli, Raffaele; Massaro, Raimondo; Forleo, Giovanni; Natale, Andrea.

In: Journal of the American College of Cardiology, Vol. 49, No. 15, 17.04.2007, p. 1634-1641.

Research output: Contribution to journalArticle

Kanj, MH, Wazni, O, Fahmy, T, Thal, S, Patel, D, Elay, C, Di Biase, L, Arruda, M, Saliba, W, Schweikert, RA, Cummings, JE, Burkhardt, JD, Martin, DO, Pelargonio, G, Dello Russo, A, Casella, M, Santarelli, P, Potenza, D, Fanelli, R, Massaro, R, Forleo, G & Natale, A 2007, 'Pulmonary Vein Antral Isolation Using an Open Irrigation Ablation Catheter for the Treatment of Atrial Fibrillation. A Randomized Pilot Study', Journal of the American College of Cardiology, vol. 49, no. 15, pp. 1634-1641. https://doi.org/10.1016/j.jacc.2006.12.041
Kanj, Mohamed H. ; Wazni, Oussama ; Fahmy, Tamer ; Thal, Sergio ; Patel, Dimpi ; Elay, Claude ; Di Biase, Luigi ; Arruda, Mauricio ; Saliba, Walid ; Schweikert, Robert A. ; Cummings, Jennifer E. ; Burkhardt, J. David ; Martin, David O. ; Pelargonio, Gemma ; Dello Russo, Antonio ; Casella, Michela ; Santarelli, Pietro ; Potenza, Domenico ; Fanelli, Raffaele ; Massaro, Raimondo ; Forleo, Giovanni ; Natale, Andrea. / Pulmonary Vein Antral Isolation Using an Open Irrigation Ablation Catheter for the Treatment of Atrial Fibrillation. A Randomized Pilot Study. In: Journal of the American College of Cardiology. 2007 ; Vol. 49, No. 15. pp. 1634-1641.
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T1 - Pulmonary Vein Antral Isolation Using an Open Irrigation Ablation Catheter for the Treatment of Atrial Fibrillation. A Randomized Pilot Study

AU - Kanj, Mohamed H.

AU - Wazni, Oussama

AU - Fahmy, Tamer

AU - Thal, Sergio

AU - Patel, Dimpi

AU - Elay, Claude

AU - Di Biase, Luigi

AU - Arruda, Mauricio

AU - Saliba, Walid

AU - Schweikert, Robert A.

AU - Cummings, Jennifer E.

AU - Burkhardt, J. David

AU - Martin, David O.

AU - Pelargonio, Gemma

AU - Dello Russo, Antonio

AU - Casella, Michela

AU - Santarelli, Pietro

AU - Potenza, Domenico

AU - Fanelli, Raffaele

AU - Massaro, Raimondo

AU - Forleo, Giovanni

AU - Natale, Andrea

PY - 2007/4/17

Y1 - 2007/4/17

N2 - Objectives: We sought to test how catheter ablation using an open irrigation catheter (OIC) compares with standard catheters for pulmonary vein antrum isolation. Background: Open irrigation catheters have the advantage of delivering greater power without increasing the temperature of the catheter tip, which enables deeper and wider lesions without the formation of coagulum on catheters. Methods: Catheter ablation was performed using an 8-mm catheter (8MC) or an OIC. Patients were randomized to 3 groups: 8MC; OIC-1, OIC with a higher peak power (50 W); and OIC-2, OIC with lower peak power (35 W). Results: A total of 180 patients were randomized to the 3 treatment strategies. Isolation of pulmonary vein antra was achieved in all patients. The freedom from atrial fibrillation was significantly greater in the 8MC and OIC-1 groups compared with the OIC-2 group (78%, 82%, and 68%, respectively, p = 0.043). Fluoroscopy time was lower in OIC-1 compared with OIC-2 and 8MC (28 ± 1 min, 53 ± 2 min, and 46 ± 2 min, respectively, p = 0.001). The mean left atrium instrumentation time was lower in the OIC-1 compared with the OIC-2 and 8MC groups (59 ± 3 min, 90 ± 5 min, and 88 ± 4 min, respectively, p = 0.001). However, there was a greater incidence of "pops" in the OIC-1 (100%, 0%, 0%, p < 0.001) along with higher incidences of pericardial effusion (20%, 0%, 0%, p < 0.001) and gastrointestinal complaints (17% in OIC-1, 3% in 8MC, and 5% in OIC-2, p = 0.031). Conclusions: Although there was a decrease in fluoroscopy and left atrium instrumentation time with the use of OIC at higher power, this setting was associated with increased cardiovascular and gastrointestinal complications.

AB - Objectives: We sought to test how catheter ablation using an open irrigation catheter (OIC) compares with standard catheters for pulmonary vein antrum isolation. Background: Open irrigation catheters have the advantage of delivering greater power without increasing the temperature of the catheter tip, which enables deeper and wider lesions without the formation of coagulum on catheters. Methods: Catheter ablation was performed using an 8-mm catheter (8MC) or an OIC. Patients were randomized to 3 groups: 8MC; OIC-1, OIC with a higher peak power (50 W); and OIC-2, OIC with lower peak power (35 W). Results: A total of 180 patients were randomized to the 3 treatment strategies. Isolation of pulmonary vein antra was achieved in all patients. The freedom from atrial fibrillation was significantly greater in the 8MC and OIC-1 groups compared with the OIC-2 group (78%, 82%, and 68%, respectively, p = 0.043). Fluoroscopy time was lower in OIC-1 compared with OIC-2 and 8MC (28 ± 1 min, 53 ± 2 min, and 46 ± 2 min, respectively, p = 0.001). The mean left atrium instrumentation time was lower in the OIC-1 compared with the OIC-2 and 8MC groups (59 ± 3 min, 90 ± 5 min, and 88 ± 4 min, respectively, p = 0.001). However, there was a greater incidence of "pops" in the OIC-1 (100%, 0%, 0%, p < 0.001) along with higher incidences of pericardial effusion (20%, 0%, 0%, p < 0.001) and gastrointestinal complaints (17% in OIC-1, 3% in 8MC, and 5% in OIC-2, p = 0.031). Conclusions: Although there was a decrease in fluoroscopy and left atrium instrumentation time with the use of OIC at higher power, this setting was associated with increased cardiovascular and gastrointestinal complications.

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