TY - JOUR
T1 - Psychosocial functioning in patients with treatment resistant depression
AU - Petersen, Timothy
AU - Papakostas, George I.
AU - Mahal, Yasmin
AU - Guyker, Wendy M.
AU - Beaumont, Erin C.
AU - Alpert, Jonathan E.
AU - Fava, Maurizio
AU - Nierenberg, Andrew A.
PY - 2004/6/1
Y1 - 2004/6/1
N2 - Background. - Depression is a disorder that causes disability, with a profound adverse impact on all areas of psychosocial functioning. This is particularly true for those with treatment resistant depression (TRD). However, to date, no systematic assessments of psychosocial functioning for patients with TRD have been conducted. Methods. - In the present study, we used the Longitudinal Interval Follow-up Evaluation (LIFE) scale to measure psychosocial functioning in 92 patients with TRD. These patients met formal criteria for TRD and were part of a clinical trial examining the efficacy of lithium augmentation of nortriptyline. Results. - Clinicians rated this sample of patients as experiencing mild to moderate impairment in work-related activities, good to fair interpersonal relations, poor level of involvement in recreational activities, and mild impairment of ability to enjoy sexual activity. Patients and clinicians rated global social adjustment as poor. Conclusions. - Patients with formally defined TRD experience significant impairment in psychosocial functioning. In this sample a tendency existed for both clinicians and patients to assign more severely impaired global ratings when compared with ratings for specific functional areas.
AB - Background. - Depression is a disorder that causes disability, with a profound adverse impact on all areas of psychosocial functioning. This is particularly true for those with treatment resistant depression (TRD). However, to date, no systematic assessments of psychosocial functioning for patients with TRD have been conducted. Methods. - In the present study, we used the Longitudinal Interval Follow-up Evaluation (LIFE) scale to measure psychosocial functioning in 92 patients with TRD. These patients met formal criteria for TRD and were part of a clinical trial examining the efficacy of lithium augmentation of nortriptyline. Results. - Clinicians rated this sample of patients as experiencing mild to moderate impairment in work-related activities, good to fair interpersonal relations, poor level of involvement in recreational activities, and mild impairment of ability to enjoy sexual activity. Patients and clinicians rated global social adjustment as poor. Conclusions. - Patients with formally defined TRD experience significant impairment in psychosocial functioning. In this sample a tendency existed for both clinicians and patients to assign more severely impaired global ratings when compared with ratings for specific functional areas.
KW - Psychosocial functioning
KW - Treatment resistant depression
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U2 - 10.1016/j.eurpsy.2003.11.006
DO - 10.1016/j.eurpsy.2003.11.006
M3 - Article
C2 - 15196600
AN - SCOPUS:2942635643
VL - 19
SP - 196
EP - 201
JO - European Psychiatry
JF - European Psychiatry
SN - 0924-9338
IS - 4
ER -