Psychosocial functioning in patients with treatment resistant depression

Timothy Petersen, George I. Papakostas, Yasmin Mahal, Wendy M. Guyker, Erin C. Beaumont, Jonathan E. Alpert, Maurizio Fava, Andrew A. Nierenberg

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background. - Depression is a disorder that causes disability, with a profound adverse impact on all areas of psychosocial functioning. This is particularly true for those with treatment resistant depression (TRD). However, to date, no systematic assessments of psychosocial functioning for patients with TRD have been conducted. Methods. - In the present study, we used the Longitudinal Interval Follow-up Evaluation (LIFE) scale to measure psychosocial functioning in 92 patients with TRD. These patients met formal criteria for TRD and were part of a clinical trial examining the efficacy of lithium augmentation of nortriptyline. Results. - Clinicians rated this sample of patients as experiencing mild to moderate impairment in work-related activities, good to fair interpersonal relations, poor level of involvement in recreational activities, and mild impairment of ability to enjoy sexual activity. Patients and clinicians rated global social adjustment as poor. Conclusions. - Patients with formally defined TRD experience significant impairment in psychosocial functioning. In this sample a tendency existed for both clinicians and patients to assign more severely impaired global ratings when compared with ratings for specific functional areas.

Original languageEnglish (US)
Pages (from-to)196-201
Number of pages6
JournalEuropean Psychiatry
Volume19
Issue number4
DOIs
StatePublished - Jun 2004
Externally publishedYes

Fingerprint

Treatment-Resistant Depressive Disorder
Nortriptyline
Social Adjustment
Aptitude
Interpersonal Relations
Lithium
Sexual Behavior
Longitudinal Studies
Clinical Trials
Depression

Keywords

  • Psychosocial functioning
  • Treatment resistant depression

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Petersen, T., Papakostas, G. I., Mahal, Y., Guyker, W. M., Beaumont, E. C., Alpert, J. E., ... Nierenberg, A. A. (2004). Psychosocial functioning in patients with treatment resistant depression. European Psychiatry, 19(4), 196-201. https://doi.org/10.1016/j.eurpsy.2003.11.006

Psychosocial functioning in patients with treatment resistant depression. / Petersen, Timothy; Papakostas, George I.; Mahal, Yasmin; Guyker, Wendy M.; Beaumont, Erin C.; Alpert, Jonathan E.; Fava, Maurizio; Nierenberg, Andrew A.

In: European Psychiatry, Vol. 19, No. 4, 06.2004, p. 196-201.

Research output: Contribution to journalArticle

Petersen, T, Papakostas, GI, Mahal, Y, Guyker, WM, Beaumont, EC, Alpert, JE, Fava, M & Nierenberg, AA 2004, 'Psychosocial functioning in patients with treatment resistant depression', European Psychiatry, vol. 19, no. 4, pp. 196-201. https://doi.org/10.1016/j.eurpsy.2003.11.006
Petersen, Timothy ; Papakostas, George I. ; Mahal, Yasmin ; Guyker, Wendy M. ; Beaumont, Erin C. ; Alpert, Jonathan E. ; Fava, Maurizio ; Nierenberg, Andrew A. / Psychosocial functioning in patients with treatment resistant depression. In: European Psychiatry. 2004 ; Vol. 19, No. 4. pp. 196-201.
@article{c6675e120c1d478d89dfe514eb6d15ee,
title = "Psychosocial functioning in patients with treatment resistant depression",
abstract = "Background. - Depression is a disorder that causes disability, with a profound adverse impact on all areas of psychosocial functioning. This is particularly true for those with treatment resistant depression (TRD). However, to date, no systematic assessments of psychosocial functioning for patients with TRD have been conducted. Methods. - In the present study, we used the Longitudinal Interval Follow-up Evaluation (LIFE) scale to measure psychosocial functioning in 92 patients with TRD. These patients met formal criteria for TRD and were part of a clinical trial examining the efficacy of lithium augmentation of nortriptyline. Results. - Clinicians rated this sample of patients as experiencing mild to moderate impairment in work-related activities, good to fair interpersonal relations, poor level of involvement in recreational activities, and mild impairment of ability to enjoy sexual activity. Patients and clinicians rated global social adjustment as poor. Conclusions. - Patients with formally defined TRD experience significant impairment in psychosocial functioning. In this sample a tendency existed for both clinicians and patients to assign more severely impaired global ratings when compared with ratings for specific functional areas.",
keywords = "Psychosocial functioning, Treatment resistant depression",
author = "Timothy Petersen and Papakostas, {George I.} and Yasmin Mahal and Guyker, {Wendy M.} and Beaumont, {Erin C.} and Alpert, {Jonathan E.} and Maurizio Fava and Nierenberg, {Andrew A.}",
year = "2004",
month = "6",
doi = "10.1016/j.eurpsy.2003.11.006",
language = "English (US)",
volume = "19",
pages = "196--201",
journal = "European Psychiatry",
issn = "0924-9338",
publisher = "Elsevier Masson",
number = "4",

}

TY - JOUR

T1 - Psychosocial functioning in patients with treatment resistant depression

AU - Petersen, Timothy

AU - Papakostas, George I.

AU - Mahal, Yasmin

AU - Guyker, Wendy M.

AU - Beaumont, Erin C.

AU - Alpert, Jonathan E.

AU - Fava, Maurizio

AU - Nierenberg, Andrew A.

PY - 2004/6

Y1 - 2004/6

N2 - Background. - Depression is a disorder that causes disability, with a profound adverse impact on all areas of psychosocial functioning. This is particularly true for those with treatment resistant depression (TRD). However, to date, no systematic assessments of psychosocial functioning for patients with TRD have been conducted. Methods. - In the present study, we used the Longitudinal Interval Follow-up Evaluation (LIFE) scale to measure psychosocial functioning in 92 patients with TRD. These patients met formal criteria for TRD and were part of a clinical trial examining the efficacy of lithium augmentation of nortriptyline. Results. - Clinicians rated this sample of patients as experiencing mild to moderate impairment in work-related activities, good to fair interpersonal relations, poor level of involvement in recreational activities, and mild impairment of ability to enjoy sexual activity. Patients and clinicians rated global social adjustment as poor. Conclusions. - Patients with formally defined TRD experience significant impairment in psychosocial functioning. In this sample a tendency existed for both clinicians and patients to assign more severely impaired global ratings when compared with ratings for specific functional areas.

AB - Background. - Depression is a disorder that causes disability, with a profound adverse impact on all areas of psychosocial functioning. This is particularly true for those with treatment resistant depression (TRD). However, to date, no systematic assessments of psychosocial functioning for patients with TRD have been conducted. Methods. - In the present study, we used the Longitudinal Interval Follow-up Evaluation (LIFE) scale to measure psychosocial functioning in 92 patients with TRD. These patients met formal criteria for TRD and were part of a clinical trial examining the efficacy of lithium augmentation of nortriptyline. Results. - Clinicians rated this sample of patients as experiencing mild to moderate impairment in work-related activities, good to fair interpersonal relations, poor level of involvement in recreational activities, and mild impairment of ability to enjoy sexual activity. Patients and clinicians rated global social adjustment as poor. Conclusions. - Patients with formally defined TRD experience significant impairment in psychosocial functioning. In this sample a tendency existed for both clinicians and patients to assign more severely impaired global ratings when compared with ratings for specific functional areas.

KW - Psychosocial functioning

KW - Treatment resistant depression

UR - http://www.scopus.com/inward/record.url?scp=2942635643&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942635643&partnerID=8YFLogxK

U2 - 10.1016/j.eurpsy.2003.11.006

DO - 10.1016/j.eurpsy.2003.11.006

M3 - Article

VL - 19

SP - 196

EP - 201

JO - European Psychiatry

JF - European Psychiatry

SN - 0924-9338

IS - 4

ER -