Protein targeting pathways and sorting signals in epithelial cells

Enrique Rodriguez-Boulan, Geri Kreitzer, David Cohen, Vera Bonilha, Anne Muesch

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A large body of knowledge has been accumulated in the last two decades on the nature of the mechanisms responsible for the polarization of epithelial cells (Rodriguez- Boulan and Nelson, 1989; Rodriguez-Boulan and Powell, 1992). Three fundamental types of mechanisms have emerged that contribute to epithelial polarity (Figure 7.1): (1) intracellular sorting and polarized delivery of proteins and lipids to the cell surface (Figure 7.1, center); (2) “trapping” interactions with domain-restricted cytoskeleton elements (Figure 7.1, right); and (3) diffusive restriction by the tight junctions (Figure 7.1, left). This chapter deals primarily with the first type.

Original languageEnglish (US)
Title of host publicationTight Junctions
PublisherCRC Press
Pages145-164
Number of pages20
ISBN (Electronic)9781420038538
ISBN (Print)9780849323836
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Rodriguez-Boulan, E., Kreitzer, G., Cohen, D., Bonilha, V., & Muesch, A. (2001). Protein targeting pathways and sorting signals in epithelial cells. In Tight Junctions (pp. 145-164). CRC Press. https://doi.org/10.1201/9781420038538