Protein structure modeling in the proteomics era

Research output: Contribution to journalReview article

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Abstract

Structural proteomics aims to understand the structural basis of protein interactions and functions. A prerequisite for this is the availability of 3D protein structures that mediate the biochemical interactions. The explosion in the number of available gene sequences set the stage for the next step in genome-scale projects - to obtain 3D structures for each protein. To achieve this ambitious goal, the slow and costly structure determination experiments are supplemented with theoretical approaches. The current state and recent advances in structure modeling approaches are reviewed here, with special emphasis on comparative protein structure modeling techniques.

Original languageEnglish (US)
Pages (from-to)97-110
Number of pages14
JournalExpert Review of Proteomics
Volume1
Issue number1
DOIs
Publication statusPublished - Dec 1 2004

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Keywords

  • Comparative/homology protein structure modeling
  • Loop modeling
  • Scoring functions
  • Sequence-to-structure alignment
  • Structural genomics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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