Protein sorting in the Golgi complex: Shifting paradigms

Enrique Rodriguez-Boulan, Anne Müsch

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations

Abstract

The paradigms for transport along the biosynthetic route have changed dramatically over the past 15 years. Unlike the situation 15 years ago, the current paradigm involves sorting signals practically at every step of the pathway. In particular, at the exit from the Golgi complex, apical, basolateral and lysosomal targeting signals result in the generation of a variety of routes. Furthermore, it is now quite clear that not all sorting in the biosynthetic route occurs in the Golgi complex or the Trans Golgi Network (TGN). Sorting may occur distally to the Golgi, in recycling endosomes or in budded tubulosaccular structures, or it may occur proximally to the Golgi complex, at the exit from the ER. Several adaptors are candidates to sort apical and basolateral proteins but only AP1B and AP4 are currently involved. Progress is fast and future work should elucidate many of the open questions.

Original languageEnglish (US)
Pages (from-to)455-464
Number of pages10
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1744
Issue number3 SPEC. ISS.
DOIs
StatePublished - Jul 10 2005
Externally publishedYes

Keywords

  • Default pathway
  • Golgi complex
  • Polarized secretion
  • Protein trafficking
  • Sorting signal

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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