Protease inhibitors do not affect antibody responses to pneumococcal vaccination

Indhira De La Rosa; Iona M. Munjal; Maria Rodriguez-Barradas; Xiaoying Yu; Liise Anne Pirofski; Daniel Mendoza

doi:10.1128/CVI.00026-16

Protease inhibitors do not affect antibody responses to pneumococcal vaccination

Indhira De La Rosa, Iona M. Munjal, Maria Rodriguez-Barradas, Xiaoying Yu, Liise Anne Pirofski, Daniel Mendoza

Research output: Contribution to journal › Article › peer-review

Abstract

HIV⁺ subjects on optimal antiretroviral therapy have persistently impaired antibody responses to pneumococcal vaccination. We explored the possibility that this effect may be due to HIV protease inhibitors (PIs). We found that in humans and mice, PIs do not affect antibody production in response to pneumococcal vaccination.

Original language	English (US)
Pages (from-to)	524-529
Number of pages	6
Journal	Clinical and Vaccine Immunology
Volume	23
Issue number	6
DOIs	https://doi.org/10.1128/CVI.00026-16
State	Published - Jun 2016

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Clinical Biochemistry
Microbiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/CVI.00026-16

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title = "Protease inhibitors do not affect antibody responses to pneumococcal vaccination",

abstract = "HIV+ subjects on optimal antiretroviral therapy have persistently impaired antibody responses to pneumococcal vaccination. We explored the possibility that this effect may be due to HIV protease inhibitors (PIs). We found that in humans and mice, PIs do not affect antibody production in response to pneumococcal vaccination.",

author = "{De La Rosa}, Indhira and Munjal, {Iona M.} and Maria Rodriguez-Barradas and Xiaoying Yu and Pirofski, {Liise Anne} and Daniel Mendoza",

year = "2016",

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language = "English (US)",

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publisher = "American Society for Microbiology",

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AU - De La Rosa, Indhira

AU - Munjal, Iona M.

AU - Rodriguez-Barradas, Maria

AU - Yu, Xiaoying

AU - Pirofski, Liise Anne

AU - Mendoza, Daniel

PY - 2016/6

Y1 - 2016/6

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AB - HIV+ subjects on optimal antiretroviral therapy have persistently impaired antibody responses to pneumococcal vaccination. We explored the possibility that this effect may be due to HIV protease inhibitors (PIs). We found that in humans and mice, PIs do not affect antibody production in response to pneumococcal vaccination.

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M3 - Article

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JO - Clinical and Vaccine Immunology

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ER -

Protease inhibitors do not affect antibody responses to pneumococcal vaccination

Abstract

ASJC Scopus subject areas

UN SDGs

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